{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:39:36Z","timestamp":1747147176184,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report outcomes and toxicity in patients who received definitive concurrent chemoradiation (DCCRT) for non\u2010operable esophageal cancer (EC) in the modern era, and to identify markers of overall and disease\u2010free survival (OS\/DFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of patients with unresectable EC who received DCCRT at our institution between 1\/2008 and 1\/2019. Descriptive statistics were used to report disease\u2010control outcomes and CTCAE v4.0\u20135.0 toxicities. Univariable and multivariable Cox regression, and stepwise regression were used to identify associations with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a median follow\u2010up of 19.5\u00a0months, 130 patients with adenocarcinoma (AC) (62%) or squamous cell carcinoma (SCC) (38%) were evaluable (Stage II\u2010III: 92%). Patients received carboplatin\/paclitaxel (75%) or fluorouracil\u2010based (25%) concurrent chemotherapy. Median total RT dose was 50.4\u00a0Gy (range, 44.7\u201371.4\u00a0Gy) delivered in 28 fractions (24\u201335). Locoregional and distant recurrence occurred in 30% and 35% of AC, and 24% and 33% of SCC, respectively. Median OS and DFS were 22.9 and 10.7\u00a0months in AC, and 25.7 and 20.2\u00a0months in SCC, respectively. On stepwise regression, tumor stage, feeding tube during DCCRT, and change in primary tumor PET\/CT SUVmax were significantly associated with OS and DFS. Most severe toxicities were acute grade 4 hematologic cytopenia (6%) and radiation dermatitis (1%). Most common acute grade 3 toxicities were hematologic cytopenia (35%), dysphagia (23%), and anorexia (19%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of non\u2010operable EC with DCCRT has acceptable toxicity and can provide multi\u2010year disease control for some patients, even in AC. Continued follow\u2010up and investigation in large studies would be useful.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3724","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T06:33:00Z","timestamp":1611210780000},"page":"1275-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The efficacy and safety of definitive concurrent chemoradiotherapy for non\u2010operable esophageal cancer"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-3094","authenticated-orcid":false,"given":"Alexandra D.","family":"Dreyfuss","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9761-3000","authenticated-orcid":false,"given":"Andrew R.","family":"Barsky","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-1128","authenticated-orcid":false,"given":"E. 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