{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:12:32Z","timestamp":1762459952551,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to examine the factors associated with disparities in overall survival (OS) by race in pediatric diffuse large B\u2010cell lymphoma (DLBCL) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated clinical features and survival among patients \u226421\u00a0years of age diagnosed with stage I\u2013IV DLBCL from 2004 to 2014 from the National Cancer Database (NCDB) using a multivariable Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1386 pediatric patients with DLBCL, 1023 patients met eligibility criteria. In unadjusted analysis, Black patients had a significantly higher overall death rate than White patients (HR<jats:sub>Black vs. White<\/jats:sub> 1.51; 95% CI: 1.02\u20132.23, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.041). The survival disparity did not remain significant in adjusted analysis, though controlling for covariates had little effect on the magnitude of the disparity (HR 1.46; 95% CI 0.93\u20132.31, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.103). In adjusted models, presence of B symptoms, receipt of chemotherapy, stage of disease, and Other insurance were significantly associated with OS. Specifically, patients with B symptoms and those with Other insurance were more likely to die than those without B symptoms or private insurance, respectively (HR 1.75; 95% CI 1.22\u20132.50, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and (HR 2.56; 95% CI, 1.39\u20134.73, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0027), patients who did not receive chemotherapy were three times more likely to die than those who received chemotherapy (HR 3.10; CI 1.80\u20135.35, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and patients who presented with earlier stage disease were less likely to die from their disease than those with stage IV disease (stages I\u2013III HR 0.34, CI 0.18\u20130.64, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; HR 0.50, CI 0.30\u20130.82, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006, HR 0.72, CI 0.43\u20131.13, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.152, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that racial disparities in survival may be mediated by clinical and treatment parameters.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3736","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T17:55:03Z","timestamp":1611770103000},"page":"1327-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations between race and survival in pediatric patients with diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"10","author":[{"given":"Karishma","family":"Khullar","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Rutgers Cancer Institute of New Jersey New Brunswick NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse J.","family":"Plascak","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Rutgers School of Public Health Piscataway NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Drachtman","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology and Oncology Rutgers Cancer Institute of New Jersey New Brunswick NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Cole","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology and Oncology Rutgers Cancer Institute of New Jersey New Brunswick NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-750X","authenticated-orcid":false,"given":"Rahul R.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rutgers Cancer Institute of New Jersey New Brunswick NJ 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