{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:10:36Z","timestamp":1790471436756,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CL040015"],"award-info":[{"award-number":["CL040015"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z01 1ZID BC011242"],"award-info":[{"award-number":["Z01 1ZID BC011242"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate outcomes and survival rates in patients with metastatic adrenocortical carcinoma (ACC) who were treated with image\u2010guided locoregional treatments (IGLTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the overall survival (OS) and clinical impact of IGLT in the management of patients with advanced metastatic ACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 39 patients treated with IGLT between 1999 and 2018 was performed. Short\u2010 and long\u2010term efficacy of treatments were defined based upon imaging and clinical data. Subgroup survival analysis was performed on patients with metastatic disease at diagnosis (N\u00a0=\u00a017) and compared with the same stage group from the most recent National Cancer Database (NCDB) report. Statistical analysis was performed using Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatments were performed at different anatomic sites including liver (N\u00a0=\u00a046), lung (N\u00a0=\u00a014), retroperitoneum (N\u00a0=\u00a05), bone (N\u00a0=\u00a04), subcutaneous (N\u00a0=\u00a02), and intracaval (N\u00a0=\u00a01). Radiofrequency, microwave, cryoablation, or a combination of two modalities (45, 18, 3, 3, respectively) were used in 69 ablation sessions. Intra\u2010arterial procedures were performed in 12 patients in 18 treatment cycles (range 1\u20133 per patient). As of a 2019 analysis, 11 patients were alive with a mean follow\u2010up of 169\u00a0months (range 63\u2013292\u00a0months) from diagnosis. Two\u2010 and 5\u2010year OS rates for all patients were 84.5% and 51%, respectively, and 76.5% and 59% for patients with metastatic disease at diagnosis (N\u00a0=\u00a017). This compares favorably with an NCDB report of 35% 5\u2010year survival rate for patients with metastatic disease. Female gender and longer time from diagnosis to first IGLT were found to be predictors of prolonged survival with hazard ratios of 0.23 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 0.66 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IGLT may be associated with prolonged life expectancy in select patients with metastatic ACC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3740","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T11:57:08Z","timestamp":1615291028000},"page":"2259-2267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term outcomes in patients with advanced adrenocortical carcinoma after image\u2010guided locoregional ablation or 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