{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:54:19Z","timestamp":1792090459313,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Papillary thyroid microcarcinoma (PTMC) has a good prognosis and a long survival time, surgery is the common treatment including total thyroidectomy (TT) and unilateral lobectomy (LT), but recent studies showed that TT does not show an advantage over LT for PTMC in preventing cancer recurrence and reducing mortality. Given this, the health\u2010related quality of life (HRQoL) has become one of the important factors that physicians must consider when making treatment decisions. The aim of this study was to compare the HRQoL of patients between undergoing TT and LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From October 2019 to December 2019, 69 PTMC patients were enrolled in our study, including 34 in the LT group and 35 in the TT group, respectively. We used three questionnaires which included the 36\u2010item short\u2010form health survey (SF\u201036), thyroid cancer\u2010specific quality of life (THYCA\u2010QOL), and Fear of Progression Questionnaire\u2010Short Form (FoP\u2010Q\u2010SF) for each patient to evaluate their scores of HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the SF\u201036, the scores of the domain for the role limitation due to physical problems, emotional problems, and social function (RP, RE, and SF) as well as Physical Component Summary (PCS) and Mental Component Summary (MCS) showed a significant negative linear association between the LT group and TT group: RP (coefficient [coef]: \u221233.953 [confidence interval (CI) \u221251.187 to \u221216.720], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, RE (coef: \u221221.633 [CI \u221239.500 to \u22123.766], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.018), SF (coef: \u221210.169 [CI \u221219.586 to \u22120.752], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.035)and PCS (coef: \u221210.571 [CI \u221217.768 to \u22123.373], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005), MCS (coef: \u221210.694 [CI \u221219.465 to \u22121.923], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.018). The THYCA\u2010QOL showed that the scores of the TT group were higher than that of the LT group in the problem of scar (coef: 16.245 [CI 1.697 to 30.794], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.029 according to the multivariate analysis), suggesting a higher level of complaint in the TT group. There was no statistically significant difference in the scores of FoP\u2010Q\u2010SF between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with PTMC, LT offers an advantage over TT in terms of HRQoL, which supports the role of LT as an alternative strategy to TT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3747","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T07:57:21Z","timestamp":1614412641000},"page":"1989-2002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The quality of life in papillary thyroid microcarcinoma patients undergoing lobectomy or total thyroidectomy: A cross\u2010sectional study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-7258","authenticated-orcid":false,"given":"Yu","family":"Lan","sequence":"first","affiliation":[{"name":"School of Medicine Nankai University Tianjin China"},{"name":"Department of Ultrasound General Hospital of Chinese PLA Beijing China"},{"name":"Department of Ultrasound The People's Hospital of Liaoning Province Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University Tianjin China"},{"name":"Department of Ultrasound General Hospital of Chinese PLA Beijing China"},{"name":"Department of General Surgery General Hospital of Chinese PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Chinese PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Chinese PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University Tianjin China"},{"name":"Department of Ultrasound General Hospital of Chinese PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Chinese PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Medicine Nankai University Tianjin China"},{"name":"Department of Ultrasound General Hospital of Chinese PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound General Hospital of Chinese PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11275"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.55"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ae5426"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.07.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3846-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000925"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3882"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0260"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2016.09.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3300-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.3870"},{"key":"e_1_2_11_15_1","volume-title":"WHO Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs","author":"Lloyd RV","year":"2017"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083362"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37838"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S99980"},{"key":"e_1_2_11_19_1","first-page":"178","article-title":"Reliability and validity of Chinese version of Thyroid Cancer\u2010specific Quality of Life (THYCA\u2010QoL) questionnaire","volume":"39","author":"Liu J","year":"2019","journal-title":"TUMOR"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.741326"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.718445"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.13109\/zptm.2006.52.3.274"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21618"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1075.132632"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4065\/77.4.371"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.139"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03424.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1203"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0242"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.03.006"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0640"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1102965"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0624"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6722"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04114.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31814697d9"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0604"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:19:26Z","timestamp":1693563566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/cam4.3747"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3747","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,26]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}