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All patients had evaluable cytogenetic analysis, and 425 patients had MDS\u2010related mutations sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>38.6% of patients displayed abnormal karyotypes. The most common cytogenetic abnormality was +8 (31%). Sole +8 was related to female (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), hemoglobin &gt;10\u00a0g\/dL (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), and &lt;60\u00a0years old (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.046). <jats:italic>TP53<\/jats:italic> mutations were associated with complex karyotype (CK) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:italic>DNMT3A<\/jats:italic> mutations correlated with \u2010Y (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) whereas <jats:italic>NRAS<\/jats:italic> mutations correlated with 20q\u2010 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). The overall survival (OS) was significantly inferior in patients with +8 compared with those with normal karyotype (NK) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). However, the OS of sole +8 and +8 with one additional karyotypic abnormality was not different from NK (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.16), but +8 with two or more abnormalities had a significantly shorter OS than +8 and +8 with one additional karyotypic abnormality (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02). In multivariable analysis, \u226560\u00a0years old, marrow blasts \u22655% and <jats:italic>TP53<\/jats:italic> mutations were independent predictors for poor OS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), whereas <jats:italic>SF3B1<\/jats:italic> mutations indicated better prognosis. Male <jats:italic>IDH1<\/jats:italic> and <jats:italic>IDH2<\/jats:italic> mutations and marrow blasts \u22655% were independent risk factors for worse leukemia free survival (LFS) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this population of Chinese patients, trisomy 8 is the most common karyotypic abnormality. Patients with +8 showed a poorer OS compared with patients with NK. Sole +8 and +8 with one additional karyotypic abnormality had similar OS with NK, whereas +8 with two or more abnormalities had a significantly shorter OS. <jats:italic>DNMT3A<\/jats:italic> mutations correlated with \u2010Y and <jats:italic>NRAS<\/jats:italic> mutations correlated with 20q\u2010. <jats:italic>TP53<\/jats:italic> mutations were associated with CK and had a poor OS. <jats:italic>SF3B1<\/jats:italic> mutations indicated a favorable OS. <jats:italic>IDH1<\/jats:italic> and <jats:italic>IDH2<\/jats:italic> mutations independently indicated inferior LFS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3786","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T03:46:27Z","timestamp":1613879187000},"page":"1759-1771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical significance of cytogenetic and molecular genetic abnormalities in 634 Chinese patients with 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