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Here, we examined the feature of inhibin\u2010\u03b1\u2010expressing cells in ovarian tumors. Immunohistochemically, inhibin\u2010\u03b1\u2010expressing tumor cells were detected only in ovarian clear cell carcinoma (OCCC) among various types of ovarian tumors. By comparing the expression of inhibin\u2010\u03b1 and Ki\u201067, inhibin\u2010\u03b1\u2010expressing tumor cells were revealed to be less proliferative. When spheroids and chemoresistant cells were derived from OCCC cell lines, the expression level of inhibin\u2010\u03b1 was elevated, and that of an immature marker, aldehyde dehydrogenase, was also elevated. In consistent with this, inhibin\u2010\u03b1 expression was correlated with other immature markers, such as OCT3\/4 and SOX2, and inversely correlated with proliferative marker MKI67 in public database on OCCC. Knockdown of inhibin\u2010\u03b1 in OCCC cell decreased chemoresistance. Moreover, prognostic analysis with 69 surgically resected OCCC cases revealed that the increased inhibin\u2010\u03b1 expression was an independent unfavorable prognostic factor. These findings suggested that inhibin\u2010\u03b1\u2010expressing subpopulation of OCCC tumor cells appeared to be less proliferative, immature, and angiogenic and to be related to acceleration of malignant progression.<\/jats:p>","DOI":"10.1002\/cam4.3801","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T05:02:29Z","timestamp":1613883749000},"page":"1485-1500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An immature inhibin\u2010\u03b1\u2010expressing subpopulation of ovarian clear cell carcinoma cells is related to an unfavorable prognosis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4551-6719","authenticated-orcid":false,"given":"Shinya","family":"Kusumoto","sequence":"first","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Kurashige","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-386X","authenticated-orcid":false,"given":"Kenji","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6134-3275","authenticated-orcid":false,"given":"Shinichiro","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-0026","authenticated-orcid":false,"given":"Satoshi","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics Department of Integrated Medicine Graduate School of Medicine, and Institute for Open and Transdisciplinary Research Initiatives Osaka University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-3650","authenticated-orcid":false,"given":"Eiichi","family":"Morii","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0065"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Clinical and histologic studies of ovarian carcinoma. 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