{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:02:13Z","timestamp":1784098933106,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This is a prospective analysis of participants free of cancer from the UK Biobank. We measured baseline body composition with electrical bioimpedance analysis and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. We documented 326 cases of cancer from 474,929 participants over a median follow\u2010up of 6.6\u00a0years. Both male (HR 1.70, 95% CI 1.01 to 2.89) and female participants (HR 2.47, 95% CI 1.15 to 5.32) in the highest quartile of whole body fat\u2010free mass were associated with increased risk of gastric cancer as compared with those in the lowest quartile.Whole body fat mass was associated with a decreased risk of gastric cancer (HR per 5\u2010unit increase 0.86, 95% CI 0.74 to 0.99) in females, but not in males. We concluded that fat\u2010free mass and fat mass may have different effects on gastric cancer risk. This study provided evidence for individualized weight management for the prevention of gastric cancer.<\/jats:p>","DOI":"10.1002\/cam4.3808","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T05:57:53Z","timestamp":1614146273000},"page":"2164-2174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Body composition and risk of gastric cancer: A population\u2010based prospective cohort study"],"prefix":"10.1002","volume":"10","author":[{"given":"An\u2010Ran","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang\u2010Sheng","family":"He","sequence":"additional","affiliation":[{"name":"Clinical Research Center Big Data Center The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Digestive Disease The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Liang","family":"Du","sequence":"additional","affiliation":[{"name":"Division of Medical Record Management The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Chong","family":"Kuo","sequence":"additional","affiliation":[{"name":"Center for Digestive Disease The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xia","sequence":"additional","affiliation":[{"name":"Clinical Research Center Big Data Center The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Clinical Research Center Big Data Center The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie C.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Center for Digestive Disease The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"},{"name":"Division of Gastroenterology School of Medicine University of California Davis Davis CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Zhen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1902-0963","authenticated-orcid":false,"given":"Yu\u2010Long","family":"He","sequence":"additional","affiliation":[{"name":"Clinical Research Center Big Data Center The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Research Center Big Data Center The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-776X","authenticated-orcid":false,"given":"Jin\u2010Qiu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Clinical Research Center Big Data Center The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition The Seventh Affiliated Hospital Sun Yat\u2010sen University Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i3.354"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"358","article-title":"Environmental and lifestyle risk factors of gastric cancer","volume":"16","author":"Lee YY","year":"2013","journal-title":"Arch Iran Med"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu082"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2019.241"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1585"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21638"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_8_11_1","unstructured":"UK Biobank\u2010Body Composition Measurement.2011.http:\/\/biobank.ctsu.ox.ac.uk\/showcase\/showcase\/docs\/body_composition.pdf(accessed Oct. 15 2020)."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00587-2"},{"issue":"12","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1158\/1055-9965.2117.13.12","article-title":"Body size and composition and risk of postmenopausal breast cancer","volume":"13","author":"Macinnis RJ","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1158\/1055-9965.553.13.4","article-title":"Body size and composition and colon cancer risk in men","volume":"13","author":"MacInnis RJ","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds244"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.04.019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.214"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000181207.02213.06"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0074-y"},{"key":"e_1_2_8_20_1","article-title":"Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) project","author":"Ferro A","year":"2019","journal-title":"Int J Cancer"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2582"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.23"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0482"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl17556"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0834"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3967"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117432"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21508"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0042"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-7-26"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3808","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:19:54Z","timestamp":1693563594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/cam4.3808"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3808","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"assertion":[{"value":"2020-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}