{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:07:33Z","timestamp":1776413253328,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The promise of speech disorders as biomarkers in clinical examination has been identified in a broad spectrum of neurodegenerative diseases. However, to the best of our knowledge, a validated acoustic marker with established discriminative and evaluative properties has not yet been developed for oral tongue cancers. Here we cross\u2010sectionally collected a screening dataset that included acoustic parameters extracted from 3 sustained vowels \/\u0251\/, \/i\/, \/u\/ and binary perceptual outcomes from 12 consonant\u2010vowel syllables. We used a support vector machine with linear kernel function within this dataset to identify the formant centralization ratio (FCR) as a dominant predictor of different perceptual outcomes across gender and syllable. The Acoustic analysis, Perceptual evaluation and Quality of Life assessment (APeQoL) was used to validate the FCR in 33 patients with primary resectable oral tongue cancers. Measurements were taken before (pre\u2010op) and four to six weeks after (post\u2010op) surgery. The speech handicap index (SHI), a speech\u2010specific questionnaire, was also administrated at these time points. Pre\u2010op correlation analysis within the APeQoL revealed overall consistency and a strong correlation between FCR and SHI scores. FCRs also increased significantly with increasing T classification pre\u2010operatively, especially for women. Longitudinally, the main effects of T classification, the extent of resection, and their interaction effects with time (pre\u2010op vs. post\u2010op) on FCRs were all significant. For pre\u2010operative FCR, after merging the two datasets, a cut\u2010off value of 0.970 produced an AUC of 0.861 (95% confidence interval: 0.785\u20130.938) for T<jats:sub>3\u20104<\/jats:sub> patients. In sum, this study determined that FCR is an acoustic marker with the potential to detect disease and related speech function in oral tongue cancers. These are preliminary findings that need to be replicated in longitudinal studies and\/or larger cohorts.<\/jats:p>","DOI":"10.1002\/cam4.3872","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T06:21:11Z","timestamp":1620022871000},"page":"3822-3835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Data mining of an acoustic biomarker in tongue cancers and its clinical validation"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8696-8033","authenticated-orcid":false,"given":"Yudong","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sien","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiqiao","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiqing","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-2357","authenticated-orcid":false,"given":"Yujie","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/1679-775720130317"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"81","article-title":"Oral squamous cell carcinoma epidemiological, clinical and histological features","volume":"41","author":"Minhas S","year":"2016","journal-title":"Rawal Med J"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wocn.2004.09.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.05.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17549507.2018.1510033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engappai.2018.09.018"},{"key":"e_1_2_10_8_1","unstructured":"V\u00e1squez\u2010CorreaJC Arias\u2010VergaraT KlumppP et al.Apkinson: A mobile solution for multimodal assessment of patients with Parkinson\u2019s disease. In: Proceedings of the Annual Conference of the International Speech Communication Association INTERSPEECH. International Speech Communication Association;2019. p.964\u2010965."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1678"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.653"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2017.1385050"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2018.05.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.104014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2016.1150604"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25949"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400604"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.424266"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2018.05.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2012.723697"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20795"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.03.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.09.007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880160404"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.21437\/Interspeech.2019-2910"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2018.2851787"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4105.1042"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00994018"},{"key":"e_1_2_10_28_1","first-page":"454","article-title":"The coarticulation resistance of consonants in standard Chinese \u2013 An electropalatographic and acoustic study","author":"Li Y","year":"2012","journal-title":"2012 8th Int Symp Chinese Spok Lang Process ISCSLP 2012"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2009.04.013"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2016.02.004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25844"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9924(02)00057-6"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2009\/08-0184)"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/17549507.2014.979880"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1123\/mcj.16.1.106"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.04.017"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23956"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699200903340758"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699200400026694"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.21437\/Interspeech.2018-1521"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/14015439.2018.1545867"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/382320"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.02.010"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21450"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.03.026"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.01.001"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.11.006"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.3872","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.3872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T06:38:44Z","timestamp":1693377524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.3872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,2]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/cam4.3872"],"URL":"https:\/\/doi.org\/10.1002\/cam4.3872","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,2]]},"assertion":[{"value":"2020-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}