{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:05:24Z","timestamp":1793642724709,"version":"4.5.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2018\u20100560"],"award-info":[{"award-number":["2018\u20100560"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prognostic factors in hepatoblastoma need to be reevaluated considering the advances in treatment modalities. The study aimed to evaluate current outcomes of hepatoblastoma and reappraise the association of prognostic factors, including pre\u2010treatment extent of tumor (PRETEXT) stage with annotation factors and Children's Hepatic tumors International Collaboration\u2010Hepatoblastoma Stratification (CHIC\u2010HS) system, with survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 103 consecutive patients with hepatoblastoma retrospectively according to the treatment period based on the introduction of a liver transplantation program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year overall survival (OS), event\u2010free survival (EFS), and transplant\u2010free survival rates were 80.2%, 74.2%, and 61.8%, respectively. EFS and OS were improved significantly from 58.6% to 81.6% (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.024) and from 58.6% to 90.8% (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), respectively, in the late period (N\u00a0=\u00a074) compared with the early period (N\u00a0=\u00a029). The PRETEXT stage was significant or marginally significant for EFS and OS in the early period but not in the late period. The P, F, R, and C factors were significant for OS and EFS in the early period. However, in the late period, only the P factor was significant for OS, and the F and M factors were significant for EFS. The CHIC\u2010HS system was significant or marginally significant for EFS in both the early and late periods; however, it was significant for OS only in the early period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Survival rates were significantly improved in children with hepatoblastoma, especially in those with advanced PRETEXT stages with positive annotation factors and in a high\u2010risk CHIC\u2010HS group. Prognostic factors had different clinical implications with evolved treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3897","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T14:15:36Z","timestamp":1620051336000},"page":"3261-3273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Recent improvement in survival outcomes and reappraisal of prognostic factors in hepatoblastoma"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-672X","authenticated-orcid":false,"given":"Kyung\u2010Nam","family":"Koh","sequence":"first","affiliation":[{"name":"Divison of Pediatric Hematology\/Oncology Department of Pediatrics Asan Medical Center Children\u2019s Hospital University of Ulsan College of Medicine Seoul 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