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Simultaneously, the healthy controls were collected from the health check\u2010up registry, and cancer\u2010free status was confirmed based on medical records. Propensity score matching was performed to reduce bias. Multinomial logit model and conditional logistic regression model were used to assess the risk of individual cancer according to HBV serological markers and classifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, 4748 patients involving seven cancers, and 57,499 controls were included. After matching, HBsAg was associated with increased risk of gastric cancer (aOR\u00a0=\u00a01.39, 95% CI: 1.05\u20131.85), and anti\u2010HBs served as a protective factor for gastric (aOR\u00a0=\u00a00.72, 95% CI: 0.61\u20130.85), colonic (aOR\u00a0=\u00a00.73, 95% CI: 0.60\u20130.89), rectal (aOR\u00a0=\u00a00.73, 95% CI: 0.63\u20130.85), and pancreatic (aOR\u00a0=\u00a00.58, 95% CI: 0.42\u20130.82) cancers. Compared to subgroups with non\u2010infection and vaccination status, inactive HBsAg carriers and active HBV infection subgroup were correlated with gastric carcinogenesis (aOR\u00a0=\u00a01.41, 95% CI: 1.03\u20131.93). However, no clear association was found between HBV infection and other cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HBV infection was potentially associated with an increased risk of gastric cancer. The development mechanism of HBV\u2010associated gastric cancer needs to investigate further.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3901","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T08:19:30Z","timestamp":1619943570000},"page":"3741-3755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Associations between hepatitis B virus exposure and the risk of extrahepatic digestive system cancers: A hospital\u2010based, case\u2013control study (SIGES)"],"prefix":"10.1002","volume":"10","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer State Key Laboratory of Biotherapy West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy Chengdu China"},{"name":"Department of Gastrointestinal Surgery The Central Hospital of Wuhan Tongji Medical College 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