{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:02:15Z","timestamp":1789570935146,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Conditional survival (CS) and failure hazard estimations can provide important dynamic prognostic information for clinical decision\u2010making and surveillance counseling. The current study aimed to investigate the CS and dynamic failure hazard in non\u2010metastatic nasopharyngeal carcinoma (NPC) treated with intensity\u2010modulated radiotherapy (IMRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Conditional overall survival (COS) and progression\u2010free survival (CPFS) estimates adjusted for age and gender against each AJCC 8th stage were calculated. Multivariable Cox regression (MCR) models were fitted in the entire population at baseline and subsequently separate MCR models were fitted in patients who have maintained event\u2010free time of 1 to 10\u00a0years to generate respective hazard ratio (HR). Annual hazard rates of death and progression over 10\u00a0years for each stage were also estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1993 patients were eligible for analysis. The estimated 5\u2010year OS and PFS for entire cohort were 79.0% and 70.7% at initial diagnosis. After 5\u00a0years of event\u2010free follow\u2010up, additional 5\u2010year COS and CPFS increased to 85.9% and 85.5%, respectively. Stage I\/II maintained dramatically favorable CS and low hazard (&lt; 5%) of death and progression over time. Relative to stage I\/II, stage III manifested non\u2010significantly higher failure hazard for the first 3\u00a0years of survivorship and approached to similar level of stage I\/II afterwards. Stage IVA presented most impressive improvement in terms of both COS (\u2206=9.8%) and CPFS (\u2206\u00a0=\u00a016.8%) whereas still drastically inferior to that of stage I\u2010III across all conditional time points. After 4\u00a0years of follow\u2010up, progression hazard of stage IVA became relatively steady of approximate 6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival prospect of non\u2010metastatic NPC improves over years with distinct dynamic patterns across stages, providing important implications for personalized decision\u2010making in terms of both clinical management and surveillance counseling. Stage\u2010dependent and hazard\u2010adapted clinical management and surveillance are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3917","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T16:02:24Z","timestamp":1620489744000},"page":"3613-3621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Stage\u2010dependent conditional survival and failure hazard of non\u2010metastatic nasopharyngeal carcinoma after intensity\u2010modulated radiation therapy: Clinical implications for treatment strategies and surveillance"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5233-5211","authenticated-orcid":false,"given":"Jingbo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runye","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical 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