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This study aimed to develop and validate nomograms and a web application to predict the overall survival (OS) of patients with non\u2010CR AML undergoing allo\u2010HCT (cord blood transplantation [CBT], bone marrow transplantation [BMT], and peripheral blood stem cell transplantation [PBSCT]). Data from 3052 patients were analyzed to construct and validate the prognostic models. The common significant prognostic factors among patients undergoing allo\u2010HCT were age, performance status, percentage of peripheral blasts, cytogenetic risk, chemotherapy response, and number of transplantations. The conditioning regimen was a significant prognostic factor only in patients undergoing CBT. Compared with cyclophosphamide\/total body irradiation, a conditioning regimen of \u22653 drugs, including fludarabine, with CBT exhibited the lowest hazard ratio for mortality (0.384; 95% CI, 0.266\u20130.554; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001). A conditioning regimen of \u22653 drugs with CBT also showed the best leukemia\u2010free survival among all conditioning regimens. Based on the results of the multivariable analysis, we developed prognostic models showing adequate calibration and discrimination (the c\u2010indices for CBT, BMT, and PBSCT were 0.648, 0.600, and 0.658, respectively). Our prognostic models can help in assessing individual risks and designing future clinical studies. Furthermore, our study indicates the effectiveness of multi\u2010drug conditioning regimens in patients undergoing CBT.<\/jats:p>","DOI":"10.1002\/cam4.3920","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:34:52Z","timestamp":1623839692000},"page":"4250-4268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Personalized prediction of overall survival in patients with AML in non\u2010complete remission undergoing allo\u2010HCT"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6684-9432","authenticated-orcid":false,"given":"Shigeki","family":"Hirabayashi","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Kyoto University Graduate School of Medicine Kyoto 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