{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:17:05Z","timestamp":1792808225573,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 CA159357"],"award-info":[{"award-number":["R03 CA159357"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA185811"],"award-info":[{"award-number":["R21 CA185811"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Young cancer survivors may be at increased risk of early\u2010onset chronic health conditions. The aim of this population\u2010based study is to estimate cardiovascular disease (CVD) risk among younger versus older B\u2010cell non\u2010Hodgkin's lymphoma (B\u2010NHL) survivors compared with their respective general population cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>B\u2010NHL survivors diagnosed from 1997 to 2015 in the Utah Cancer Registry were matched with up to five cancer\u2010free individuals on birth year, sex, and birth state, using the statewide Utah Population Database. Electronic medical records and statewide health care facility data were used to identify disease outcomes \u22655\u00a0years after cancer diagnosis. Cox Proportional Hazards models were used to estimate hazard ratios for B\u2010NHL survivors diagnosed at &lt;65\u00a0years and \u226565\u00a0years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Younger B\u2010NHL survivors had higher relative risks than older cancer survivors of chronic rheumatic disease of the heart valves (HR = 4.14, 99% CI = 2.17\u20137.89; <jats:italic>P<\/jats:italic> value<jats:sub>heterogeneity<\/jats:sub> = 0.004); peri\u2010, endo\u2010, and myocarditis (HR = 2.43, 99% CI = 1.38\u20134.28; <jats:italic>P<\/jats:italic> value<jats:sub>heterogeneity<\/jats:sub> = 0.016); diseases of the arteries (HR = 1.63, 99% CI = 1.21\u20132.21; <jats:italic>P<\/jats:italic> value<jats:sub>heterogeneity<\/jats:sub> = 0.044); and hypotension (HR = 2.44, 99% CI = 1.58\u20133.75; <jats:italic>P<\/jats:italic> value<jats:sub>heterogeneity<\/jats:sub> = 0.048). B\u2010NHL survivors of both age groups had elevated relative risks of heart disease overall and congestive heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Younger B\u2010NHL survivors had higher risks than older B\u2010NHL survivors of specific cardiovascular diseases compared to their respective general population cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3934","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T15:37:05Z","timestamp":1620833825000},"page":"4117-4126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiovascular disease risks in younger versus older adult B\u2010cell non\u2010Hodgkin\u2019s lymphoma survivors"],"prefix":"10.1002","volume":"10","author":[{"given":"Krista","family":"Ocier","sequence":"first","affiliation":[{"name":"Division of Public Health Department of Family &amp; Preventive Medicine University of Utah School of Medicine Salt Lake City UT USA"},{"name":"Huntsman Cancer Institute Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Public Health Department of Family &amp; Preventive Medicine University of Utah School of Medicine Salt Lake City UT USA"},{"name":"Huntsman Cancer Institute Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Rowe","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Snyder","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"University of Utah Health Sciences Center Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Newman","sequence":"additional","affiliation":[{"name":"University of Utah Health Sciences Center Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Fraser","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource Population Sciences Huntsman Cancer Institute Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Smith","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource Population Sciences Huntsman Cancer Institute Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Porucznik","sequence":"additional","affiliation":[{"name":"Division of Public Health Department of Family &amp; Preventive Medicine University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Shoaf","sequence":"additional","affiliation":[{"name":"Division of Public Health Department of Family &amp; Preventive Medicine University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Stanford","sequence":"additional","affiliation":[{"name":"Division of Public Health Department of Family &amp; Preventive Medicine University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-8955","authenticated-orcid":false,"given":"Catherine J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies Department of Internal Medicine University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-2049","authenticated-orcid":false,"given":"Mia","family":"Hashibe","sequence":"additional","affiliation":[{"name":"Division of Public Health Department of Family &amp; Preventive Medicine University of Utah School of Medicine Salt Lake City UT USA"},{"name":"Huntsman Cancer Institute Salt Lake City UT USA"},{"name":"Utah Cancer Registry University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"National Cancer institute surveillance epidemiology and end results program. 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