{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:37:37Z","timestamp":1747147057775,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While docetaxel\/cisplatin\/5\u2010fluorouracil (DCF) outperforms CF in first\u2010line gastric adenocarcinoma, toxicity remains an issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter phase II trial randomized chemona\u00efve metastatic gastric adenocarcinoma patients to fractionated weekly DCF (D 40\u00a0mg\/m<jats:sup>2<\/jats:sup>, C 35\u00a0mg\/m\u00b2, F 1800\u00a0mg\/m\u00b2 over 24\u00a0h, on days 1 and 8 every 3\u00a0weeks, arm (1) or fortnightly DCF (D 50\u00a0mg\/m<jats:sup>2<\/jats:sup>, C 50\u00a0mg\/m\u00b2, F 2000\u00a0mg\/m\u00b2 over 48\u00a0h every 2\u00a0weeks, arm (2). Prophylactic granulocyte colony\u2010stimulating factor (G\u2010CSF) was not allowed. The primary endpoint was\u00a0the rate of febrile neutropenia within the first six treatment weeks (early FN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 106 eligible patients were recruited. The early and overall FN rates were 9.5% and 17% in arm 1, respectively, and 5.9% and 8% in arm 2, respectively. Grade \u22653 toxicities occurred in 81% of patients in arm 1 and 90% of patients in arm 2, the most common being\u00a0neutropenia (33% vs. 61%), fatigue (27% vs. 25%), vomiting (21% vs. 12%), anorexia (19% vs. 18%), and diarrhea (17% vs. 10%).\u00a0Median progression\u2010free survival and overall survival were 5.1 (95% CI, 3.2\u20136.5) and 8.2\u00a0months (95% CI, 6.0\u201314.5), respectively, in arm 1 and 5.2 (95% CI, 3.0\u20136.9) and 11.9\u00a0months (95% CI, 7.4\u201315.9), respectively, in arm 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fractionated weekly and fortnightly DCF regimens are associated with a low risk of early FN, and a better hematological toxicity profile as compared to historical DCF without compromising efficacy. Both regimens offer greater convenience removing the need for systematic use of prophylactic G\u2010CSF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.3976","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T12:27:59Z","timestamp":1622464079000},"page":"4366-4374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fortnightly or fractionated weekly docetaxel\u2013cisplatin\u20135\u2010FU as first\u2010line treatment in advanced gastric and gastroesophageal junction adenocarcinoma: The randomized phase II DoGE study"],"prefix":"10.1002","volume":"10","author":[{"given":"Am\u00e9lie","family":"Deleporte","sequence":"first","affiliation":[{"name":"Department of Medicine Gastrointestinal Unit Institut Jules Bordet Universit\u00e9 Libre de Bruxelles Bruxelles Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Van den 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