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Studies involving patients treated with cisplatin\u2010based chemoradiotherapy were selected and reviewed by at least two independent reviewers, with disagreements resolved by a third reviewer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>A total of 737\u00a0studies were identified, of which 314 assessed immune biomarkers in immunocompetent patients (30 included in the final analysis) and 327\u00a0studies in immunosuppressed patients (5 included in the final analysis). The strongest prognostic indicators were lymphopenia and elevated neutrophil\u2010to\u2010lymphocyte ratio. Other potential markers included HPV\u2010specific lymphocyte response, cytokine profile, expression of immune\u2010blocking antigens on cell surfaces, and tumor\u2010associated lymphocyte, macrophage, and neutrophil infiltration. Studies of immunosuppressed patients described more severe cytopenic changes overall and concluded that viral suppression led to improved outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The immunologic interplay at work in cervical cancer development, progression, and treatment is complex. Strong evidence was found in favor of lymphopenia and elevated neutrophil\u2010to\u2010lymphocyte ratio being prognostic for worse outcomes with other markers showing potential associations as well. Although the interpretation of immune status with regard to treatment approach remains unclear, future studies should aim to tailor treatment that minimizes possible detrimental immune effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.4017","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T03:41:36Z","timestamp":1623469296000},"page":"4206-4220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Immune correlates of therapy outcomes in women with cervical cancer treated with chemoradiotherapy: A systematic review"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-1003","authenticated-orcid":false,"given":"David S.","family":"Lakomy","sequence":"first","affiliation":[{"name":"Departments of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Dartmouth Geisel School of Medicine Hanover NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Wu","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"The University of Texas School of Public Health Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Lombe","sequence":"additional","affiliation":[{"name":"Cancer Diseases Hospital Lusaka Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Papasavvas","sequence":"additional","affiliation":[{"name":"Departments of Immunology, Microenvironment &amp; Metastasis Program The Wistar Institute Cancer Center Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Citonje","family":"Msadabwe","sequence":"additional","affiliation":[{"name":"Cancer Diseases Hospital Lusaka Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Geng","sequence":"additional","affiliation":[{"name":"Research Medical Library The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"Montaner","sequence":"additional","affiliation":[{"name":"Departments of Immunology, Microenvironment &amp; Metastasis Program The Wistar Institute Cancer Center Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Chiao","sequence":"additional","affiliation":[{"name":"Departments of General Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Departments of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilie L.","family":"Lin","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800909788486722"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.02.026"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32470-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4368"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01575-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23704"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30149-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu238"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610120085618"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"183.e181","article-title":"A randomized clinical trial comparing cervical dysplasia treatment with cryotherapy vs loop electrosurgical excision procedure in HIV\u2010seropositive women from Johannesburg","volume":"217","author":"Smith JS","year":"2017","journal-title":"South Africa. 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