{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:16:43Z","timestamp":1782325003935,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The incidence of cardiovascular events among cancer patients with bone metastases is poorly understood. We examined rates of cardiovascular events among cancer patients with bone metastases and mortality following such events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using Danish health registries, we identified all Danish cancer patients diagnosed with bone metastases (1994\u20132013) and followed them from bone metastasis diagnosis. We computed incidence rates (IR) per 100 person\u2010years and cumulative incidence for first\u2010time inpatient hospitalization or outpatient clinic visit for cardiovascular events, defined as myocardial infarction, ischemic stroke, or venous thromboembolism (VTE). We also analyzed all\u2010cause mortality rates including cardiovascular events as time\u2010varying exposure with adjustment for age, sex, and Charlson Comorbidity Index score. All analyses were performed overall and stratified by cancer type (prostate, breast, lung, and other).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 23,113 cancer patients with bone metastases. The cumulative incidence of cardiovascular events was 1.3% at 30\u00a0days, 3.7% at 1\u00a0year, and 5.2% at 5\u00a0years of follow\u2010up. The highest IR was observed for VTE, followed by ischemic stroke and myocardial infarction, both overall and by cancer types. Lung cancer patients with bone metastases had the highest incidence of cardiovascular events followed by prostate and breast cancer. Occurrence of any cardiovascular event was a strong predictor of death (5\u00a0years following the event, the adjusted hazard ratio was 1.8 [95% confidence interval: 1.7\u20131.9]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cancer patients with bone metastases had a substantial risk of developing cardiovascular events, and these events were associated with a subsequent increased mortality. Our findings underscore the importance of continuous optimized prevention of and care for cardiovascular disease among cancer patients with bone metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4027","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T16:44:46Z","timestamp":1622652286000},"page":"4885-4895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cardiovascular events in cancer patients with bone metastases\u2014A Danish population\u2010based cohort study of 23,113 patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-8578","authenticated-orcid":false,"given":"Peter H.","family":"Asdahl","sequence":"first","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus N Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus N 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