{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:10:58Z","timestamp":1778987458296,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA229834"],"award-info":[{"award-number":["R01CA229834"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K24CA201543"],"award-info":[{"award-number":["K24CA201543"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with previous cancer are often excluded from clinical trials despite limited evidence about their prognosis. We examined the effect of previous cancer on overall and colorectal cancer (CRC)\u2010specific survival of patients newly diagnosed with CRC. This population\u2010based cohort study from the U.S.A. included patients aged \u226566\u00a0years and diagnosed with CRC between 2005 and 2015 in linked Surveillance, Epidemiology, and End Results\u2010Medicare data. We estimated the stage\u2010specific effects of a previous cancer on overall survival using Cox regression and on CRC\u2010specific survival using competing risk regression. We also examined the effect of previous cancer type, timing, and stage on overall survival. Of 112,769 patients, 14.1% were previously diagnosed with another cancer\u2013\u2013commonly prostate (32.9%) or breast (19.4%) cancer, with many (47.1%) diagnosed &lt;5\u00a0years of CRC. For all CRC stages except IV, in which there was no difference, patients with previous cancer (vs. without) had worse overall survival. However, patients with previous cancer had <jats:italic>improved<\/jats:italic> CRC\u2010specific survival. Overall survival for those with stage 0\u2013III CRC varied by previous cancer type, timing, and stage; for example, patients with previous melanoma had overall survival equivalent to those with no previous cancer. Our results indicate that, in general, CRC patients with previous cancer have worse overall survival but superior CRC\u2010specific survival. Given their equivalent survival to those without previous cancer, patients with previous melanoma and those with stage IV CRC with any type of previous cancer should be eligible to participate in clinical trials.<\/jats:p>","DOI":"10.1002\/cam4.4036","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T07:37:09Z","timestamp":1625125029000},"page":"4752-4767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Survival of patients newly diagnosed with colorectal cancer and with a history of previous cancer"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-9176","authenticated-orcid":false,"given":"Sandi L.","family":"Pruitt","sequence":"first","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Harold C. Simmons Comprehensive Cancer Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7812-6741","authenticated-orcid":false,"given":"David E.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Harold C. Simmons Comprehensive Cancer Center Dallas TX USA"},{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8562-3351","authenticated-orcid":false,"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Harold C. Simmons Comprehensive Cancer Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Heitjan","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Department of Statistical Science Southern Methodist University Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhumika","family":"Maddineni","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyi","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Department of Statistical Science Southern Methodist University Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit G.","family":"Singal","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Harold C. Simmons Comprehensive Cancer Center Dallas TX USA"},{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-9085","authenticated-orcid":false,"given":"Anna","family":"Tavakkoli","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Harold C. Simmons Comprehensive Cancer Center Dallas TX USA"},{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan A.","family":"Halm","sequence":"additional","affiliation":[{"name":"Department of Population &amp; Data Sciences University of Texas Southwestern Medical Center Dallas TX USA"},{"name":"Harold C. 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Simmons Comprehensive Cancer Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0133"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0782"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.3605"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"41","article-title":"Metachronous Cancer","volume":"96","author":"Glicksman AS","year":"2013","journal-title":"R I Med J"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0203-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2876-y"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.4186"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju302"},{"key":"e_1_2_11_10_1","unstructured":"MurphyCC GarciaS PerezM et al.Impact of prior cancer on enrollment in clinical trials of gastrointestinal cancer. 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