{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:48:52Z","timestamp":1779914932497,"version":"3.53.1"},"reference-count":43,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005567","name":"H. Lee Moffitt Cancer Center and Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005567","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cyclin\u2010dependent kinase 4 and 6 (CDK4\/6) inhibitor targeted therapies dramatically improve survival outcomes for metastatic breast cancer (MBC), but they are associated with significant symptom burden that can impact patients\u2019 health\u2010related quality of life (HRQOL) and treatment outcomes. This study is the first to describe CDK4\/6 inhibitor symptoms from the lived perspectives of MBC patients taking CDK4\/6 inhibitors and healthcare providers involved in MBC care. This study also explored patients\u2019 symptom management and HRQOL concerns, and gathered feedback about developing supportive interventions for MBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MBC patients taking CDK4\/6 inhibitors (<jats:italic>N<\/jats:italic>\u00a0=\u00a020) and MBC healthcare providers (<jats:italic>N<\/jats:italic>\u00a0=\u00a012) participated in semi\u2010structured interviews that were analyzed for qualitative themes. MBC patients completed surveys about HRQOL, symptoms, and unmet needs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient and provider perceptions of CDK4\/6 inhibitor symptoms did not align with patients perceiving symptoms as more burdensome. Patients reported that supportive resources (e.g., support groups, blogs) that are not specific to MBC do not adequately meet their needs. Patients and providers were enthusiastic about developing supportive interventions specifically for MBC and offered considerations for designing such interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings highlight differences in perceptions of CDK4\/6 inhibitor symptom burden between MBC patients and providers. Results will inform the development of supportive interventions to assist MBC patients in managing CDK4\/6 inhibitor symptom burden and maintaining HRQOL. Such interventions could also improve treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4055","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T10:40:20Z","timestamp":1624531220000},"page":"4823-4831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A mixed\u2010methods study of cyclin\u2010dependent kinase 4 and 6 inhibitor symptom burden and quality of life among metastatic breast cancer patients and providers"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6281-2512","authenticated-orcid":false,"given":"Laura B.","family":"Oswald","sequence":"first","affiliation":[{"name":"Health Outcomes and Behavior Program Moffitt Cancer Center Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandy","family":"Arredondo","sequence":"additional","affiliation":[{"name":"Participant Research, Interventions, and Measurement Core Moffitt Cancer Center Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kadono","sequence":"additional","affiliation":[{"name":"Institute for Health Equity AltaMed Health Services Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinorah","family":"Martinez\u2010Tyson","sequence":"additional","affiliation":[{"name":"College of Public Health University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy D.","family":"Meade","sequence":"additional","affiliation":[{"name":"Health Outcomes and Behavior Program Moffitt Cancer Center Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Penedo","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Miami Coral Gables FL USA"},{"name":"Department of Medicine University of Miami Coral Gables FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Miami Coral Gables FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6644-2264","authenticated-orcid":false,"given":"Hatem","family":"Soliman","sequence":"additional","affiliation":[{"name":"Breast Oncology Program Moffitt Cancer Center Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo L. 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