{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:19:49Z","timestamp":1789957189472,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30\u2010CA008748"],"award-info":[{"award-number":["P30\u2010CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We examined the characteristics of breast cancer patients with oligometastases (OM) treated with stereotactic ablative body radiotherapy (SABR) to identify factors associated with local progression, distant metastasis progression, time to subsequent therapy, progression\u2010free survival (PFS), and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed a single\u2010institution database of patients treated with radiotherapy between 2008 and 2018 and identified 79 patients who received SABR to OM. Twenty\u2010seven patients had genetic testing of metastatic tumors using an institutional targeted sequencing platform. Kaplan\u2013Meier analysis, Cox regression, and competing risk models were used to compare clinical and genetic correlates with outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was 50\u00a0months (IQR: 29\u201366) with 67% of patients alive at the last follow\u2010up. Of the 65% of patients who progressed, 82% progressed outside of the radiation field, 18% experienced local failure, and 80% had oligoprogression. Median OS was 86\u00a0months (IQR: 29\u201366), and PFS was 33\u00a0months (IQR: 10\u201338). Less than 5\u00a0years from diagnosis to SABR and triple\u2010negative breast cancer (TNBC) were associated with worse OS. Advanced T stage, any prior chemotherapy, and TNBC were associated with worse PFS. Alterations in CEBPB, RB1, TBX3, PTEN, and CDK4 were associated with worse survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term systemic disease control and survival can be achieved with SABR for oligometastatic breast cancer. Hormone receptor\u2010positive patients with a long disease interval from initial diagnosis and limited systemic progression history may be ideal for SABR to all sites of disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4068","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T06:22:49Z","timestamp":1624429369000},"page":"5163-5174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Long\u2010term disease control and survival observed after stereotactic ablative body radiotherapy for oligometastatic breast cancer"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-4691","authenticated-orcid":false,"given":"N. Ari","family":"Wijetunga","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos H.","family":"dos Anjos","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Solid Tumor Oncology Breast Medicine Service Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4263-7272","authenticated-orcid":false,"given":"W. Iris","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Solid Tumor Oncology Breast Medicine Service Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Robson","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Solid Tumor Oncology Breast Medicine Service Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Jillian","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"},{"name":"Precision Radiation for Oligometastatic and Metastatic Disease (PROMISE) Program Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"},{"name":"Precision Radiation for Oligometastatic and Metastatic Disease (PROMISE) Program Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dover","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY USA"},{"name":"Precision 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