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We simulated women identified as first\u2010degree relatives (FDR) with LS of colorectal cancer patients after universal testing for LS. We estimated costs and benefits of offering this cohort PH, accounting for reduced quality of life after PH and for having EC. Three minimum ages (30\/35\/40) and three maximum ages (70\/75\/80) were compared to no PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the absence of PH, the estimated number of EC cases was 300 per 1,000 women with LS. Total associated costs for treatment of EC were $5.9\u00a0million. Offering PH to FDRs aged 40\u201380\u00a0years was considered optimal. This strategy reduced the number of endometrial cancer cases to 5.4 (\u221298%), resulting in 516 quality\u2010adjusted life years (QALY) gained and increasing the costs (treatment of endometrial cancer and PH) to $15.0\u00a0million (+154%) per 1,000 women. PH from earlier ages was more costly and resulted in fewer QALYs, although this finding was sensitive to disutility for PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Offering PH to 40\u2010 to 80\u2010year\u2010old women with LS is expected to add 0.5 QALY per person at acceptable costs. Women may decide to have PH at a younger age, depending on their individual disutility for PH and premature menopause.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4080","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T18:23:54Z","timestamp":1631471034000},"page":"6835-6844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cost\u2010effectiveness of prophylactic hysterectomy in first\u2010degree female relatives with Lynch syndrome of patients diagnosed with colorectal cancer in the United States: a microsimulation study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2690-8810","authenticated-orcid":false,"given":"Maaike","family":"Alblas","sequence":"first","affiliation":[{"name":"Department of Public Health Erasmus MC\u2013University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4249-6169","authenticated-orcid":false,"given":"Elisabeth F. 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