{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:58:36Z","timestamp":1787500716448,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abdominal size is associated positively with the risk of some cancers but the influence of body mass index (BMI) and gluteofemoral size is unclear because waist and hip circumference are strongly correlated with BMI. We examined associations of 33 cancers with A Body Shape Index (ABSI) and hip index (HI), which are independent of BMI by design, and compared these with waist and hip circumference, using multivariable Cox proportional hazards models in UK Biobank. During a mean follow\u2010up of 7\u00a0years, 14,682 incident cancers were ascertained in 200,289 men and 12,965 cancers in 230,326 women. In men, ABSI was associated positively with cancers of the head and neck (hazard ratio HR\u00a0=\u00a01.14; 95% confidence interval 1.03\u20131.26 per one standard deviation increment), esophagus (adenocarcinoma, HR\u00a0=\u00a01.27; 1.12\u20131.44), gastric cardia (HR\u00a0=\u00a01.31; 1.07\u20131.61), colon (HR\u00a0=\u00a01.18; 1.10\u20131.26), rectum (HR\u00a0=\u00a01.13; 1.04\u20131.22), lung (adenocarcinoma, HR\u00a0=\u00a01.16; 1.03\u20131.30; squamous cell carcinoma [SCC], HR\u00a0=\u00a01.33; 1.17\u20131.52), and bladder (HR\u00a0=\u00a01.15; 1.04\u20131.27), while HI was associated inversely with cancers of the esophagus (adenocarcinoma, HR\u00a0=\u00a00.89; 0.79\u20131.00), gastric cardia (HR\u00a0=\u00a00.79; 0.65\u20130.96), colon (HR\u00a0=\u00a00.92; 0.86\u20130.98), liver (HR\u00a0=\u00a00.86; 0.75\u20130.98), and multiple myeloma (HR\u00a0=\u00a00.86; 0.75\u20131.00). In women, ABSI was associated positively with cancers of the head and neck (HR\u00a0=\u00a01.27; 1.10\u20131.48), esophagus (SCC, HR\u00a0=\u00a01.37; 1.07\u20131.76), colon (HR\u00a0=\u00a01.08; 1.01\u20131.16), lung (adenocarcinoma, HR\u00a0=\u00a01.17; 1.06\u20131.29; SCC, HR\u00a0=\u00a01.40; 1.20\u20131.63; small cell, HR\u00a0=\u00a01.39; 1.14\u20131.69), kidney (clear\u2010cell, HR\u00a0=\u00a01.25; 1.03\u20131.50), and post\u2010menopausal endometrium (HR\u00a0=\u00a01.11; 1.02\u20131.20), while HI was associated inversely with skin SCC (HR\u00a0=\u00a00.91; 0.83\u20130.99), post\u2010menopausal kidney cancer (HR\u00a0=\u00a00.77; 0.67\u20130.88), and post\u2010menopausal melanoma (HR\u00a0=\u00a00.90; 0.83\u20130.98). Unusually, ABSI was associated inversely with melanoma in men (HR\u00a0=\u00a00.89; 0.82\u20130.96) and pre\u2010menopausal women (HR\u00a0=\u00a00.77; 0.65\u20130.91). Waist and hip circumference reflected associations with BMI, when examined individually, and provided biased risk estimates, when combined with BMI. In conclusion, preferential positive associations of ABSI or inverse of HI with several major cancers indicate an important role of factors determining body shape in cancer development.<\/jats:p>","DOI":"10.1002\/cam4.4097","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T02:02:59Z","timestamp":1625191379000},"page":"5614-5628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["A Body Shape Index (ABSI), hip index, and risk of cancer in the UK Biobank cohort"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-4436","authenticated-orcid":false,"given":"Sofia","family":"Christakoudi","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Imperial College London Norfolk Place, London UK"},{"name":"MRC Centre for Transplantation King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-8472","authenticated-orcid":false,"given":"Konstantinos K.","family":"Tsilidis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Imperial College London Norfolk Place, London UK"},{"name":"Department of Hygiene and Epidemiology University of Ioannina School of Medicine Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Evangelou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Imperial College London Norfolk Place, London UK"},{"name":"Department of Hygiene and Epidemiology University of Ioannina School of Medicine Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Riboli","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Imperial College London Norfolk Place, London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1606602"},{"key":"e_1_2_9_3_1","article-title":"Obesity associated disease risk: the role of inherent differences and location of adipose depots","volume":"33","author":"Hill JH","year":"2018","journal-title":"Horm Mol Biol Clin Investig"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"e13088","DOI":"10.1111\/obr.13088","article-title":"Visceral obesity and incident cancer and cardiovascular disease: an integrative review of the epidemiological evidence","volume":"22","author":"Silveira EA","year":"2020","journal-title":"Obes Rev"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71302-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039504"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8094275"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol119"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185013"},{"key":"e_1_2_9_10_1","unstructured":"UK Biobank Coordinating Centre; UK.Protocol for a large\u2010scale prospective epidemiological resource. 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