{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:56:20Z","timestamp":1774065380106,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The optimal sequence for the administration of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for treating non\u2010small cell lung cancer (NSCLC) is still unclear. This study aimed to evaluate the efficacy of sequential afatinib and osimertinib treatment in patients with NSCLC harboring EGFR mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Electronic records of patients with EGFR\u2010mutated NSCLC, who were administered afatinib and osimertinib (group A) or other chemotherapy (group B) between October 2014 and 2019, across 16 hospitals in South Korea were reviewed. The primary outcome, time on treatment (TOT), secondary outcome, and overall survival (OS) were estimated using the Kaplan\u2013Meier method and log\u2010rank test. Multivariate analyses were performed using the Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 737 patients who received frontline afatinib treatment, 324 with complete records were selected (group A: 126, group B: 198). All patients in group A were T790M positive after afatinib, while patients in group B were all negative or unknown. The median TOT was 35.4 months (95% confidence interval [CI]: 27.7\u221245.6) in group A and 20.8 months (95% CI: 19.4\u221224.0) in group B. The median TOT with afatinib was 13.0 months (95% CI: 12.0\u221213.9) overall and 15.7 months (95% CI: 13.9\u221217.3) in group A. The 2\u2010 and 3\u2010year survival rates were 86.0 and 69.3% in group A and 75.9 and 55.3% in group B, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sequential afatinib and osimertinib treatment resulted in better survival rates than treatment with afatinib followed by other chemotherapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4127","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T05:52:25Z","timestamp":1626241945000},"page":"5809-5822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sequential treatment of afatinib and osimertinib or other regimens in patients with advanced non\u2010small\u2010cell lung cancer harboring EGFR mutations: Results from a real\u2010world study in South Korea"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-5051","authenticated-orcid":false,"given":"Taeyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine The Armed Forces Goyang Hospital Goyang\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Won","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kosin University College of Medicine Kosin University Gospel Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ulsan University Asan Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research Institute Pusan National University Hospital Pusan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Allergy, and Critical Care Medicine Department of Internal Medicine Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol\u2010Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Soo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Gangnam Severance Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Konkuk University Medical 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