{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:45:55Z","timestamp":1780447555906,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81761128006"],"award-info":[{"award-number":["81761128006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2016\u2010I2M\u20101\u2010019"],"award-info":[{"award-number":["2016\u2010I2M\u20101\u2010019"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001547","name":"China Medical Board","doi-asserted-by":"publisher","award":["16\u2010255"],"award-info":[{"award-number":["16\u2010255"]}],"id":[{"id":"10.13039\/100001547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the clinical performance of liquid\u2010based cytology (LBC), HPV tests and visual inspections with acetic acid or Lugol's iodine (VIA\/VILI) as primary screening and triage strategies among Chinese women living with HIV (WLHIV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>WLHIV aged 18\u00a0years and older were recruited from HIV\/AIDS treatment clinic in Yunnan, China from 2019 to 2020. Women were screened with self\u2010 and physician\u2010sampling for HPV tests, LBC, and VIA\/VILI. Women positive for any HPV or with cytological abnormalities were recalled for colposcopy examination and biopsy when necessary. Clinical performance of primary and triage strategies for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For primary screening, sensitivity of physician\u2010HPV tests was 100%, 89.5%, and 100% for hybrid capture 2 (HC2), cobas, and Sansure HPV, and specificity was 80.4%, 85.1%, and 72.0%, respectively. Self\u2010HPV test achieved considerable performance with physician\u2010HPV. Sensitivity and specificity were 61.1% and 96.3% for LBC (atypical squamous cells of undetermined significance or worse [ASCUS+]), 40.0% and 77.3% for VIA\/VILI. For triaging HPV\u2010positive women, LBC (ASCUS+), HPV\u201016\/18 genotyping, and VIA\/VILI\u2010elevated specificity with sensitivity declined 30%\u201350% compared with HPV screening alone. Restricted HPV genotyping triage (HPV\u201016\/18\/31\/33\/45\/52\/58) demonstrated the optimal accuracy (89.5% sensitivity, 81.9% specificity), and was similar to HPV\u201016\/18 with reflex LBC (ASCUS+). Combination antiretroviral therapies (cARTs) &lt;2\u00a0years were associated with decreased specificity of HC2 (aOR: 1.87, 95% CI: 1.22\u20133.91) and Sansure HPV (2.48, 1.43\u20134.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Self\u2010HPV with restricted genotyping triage is highly recommended for cervical cancer screening for WLHIV in China. Feasible triage to increase HPV specificity among women with short duration of cART is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4152","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T06:45:19Z","timestamp":1627973119000},"page":"6078-6088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Performance of cervical cancer screening and triage strategies among women living with HIV in China"],"prefix":"10.1002","volume":"10","author":[{"given":"Rufei","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The First Affiliated Hospital of Kunming Medical University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuye","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Third People's Hospital of Kunming Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Third People's Hospital of Kunming Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605756"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000336"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30459-9"},{"key":"e_1_2_9_5_1","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","author":"CDC","year":"1993","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_9_6_1","unstructured":"WHO.WHO Director\u2010General calls for all countries to take action to help end the suffering caused by cervical cancer.https:\/\/www.who.int\/reproductivehealth\/call\u2010to\u2010action\u2010elimination\u2010cervical\u2010cancer\/en\/. 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