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Little is known whether racial disparities exist in neutropenia associated with taxanes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a diagnosis of primary cancer who underwent chemotherapy with taxanes were identified from Vanderbilt University Medical Center's Synthetic Derivative. Multinomial regression models were applied to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) of neutropenia associated with race, with adjustments for demographic variables, baseline neutrophil count, chemotherapy\u2010related information, prior treatments, and cancer site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3492 patients were included in the study. Compared with White patients, grade 2 or higher neutropenia was more frequently recorded among Black patients who received taxanes overall (42.2% vs. 32.7%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) or paclitaxel (43.0% vs. 36.7%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) but not among those who received docetaxel (32.0% vs. 30.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.821). After adjustments for multiple covariates, Black patients who received chemotherapy with any taxanes had significantly higher risk of grade 2 (OR\u00a0=\u00a01.53; 95% CI\u00a0=\u00a01.09\u20132.14) and grade 3 (OR\u00a0=\u00a01.91; 95% CI\u00a0=\u00a01.36\u20132.67) neutropenia but comparable risk of grade 4 neutropenia (OR\u00a0=\u00a01.19; 95% CI\u00a0=\u00a00.79\u20131.79). Similar association patterns were observed for Black patients who specifically received paclitaxel, but a null association was found for those treated with docetaxel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Black cancer patients treated with taxanes for any cancer had a higher risk of neutropenia compared with their White counterparts, especially those who received paclitaxel. More research is needed to understand the mechanism(s) underlying this racial disparity in order to enhance the delivery of patient\u2010centered oncology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4181","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T18:14:12Z","timestamp":1632248052000},"page":"6767-6776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Racial disparity in taxane\u2010induced neutropenia among cancer patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-0773","authenticated-orcid":false,"given":"Neil S.","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Department of Medicine Vanderbilt\u2010Ingram Cancer Center Vanderbilt University Medical Center Nashville TN USA"},{"name":"Department of Breast Surgery The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine Vanderbilt\u2010Ingram Cancer Center Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Qi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Berlin","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine Vanderbilt\u2010Ingram Cancer Center Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-8314","authenticated-orcid":false,"given":"Xiao\u2010Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Department of Medicine Vanderbilt\u2010Ingram Cancer Center Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_9_3_1","first-page":"1","article-title":"Cancer facts & figures 2020","volume":"76","author":"American Cancer Society","year":"2020","journal-title":"Am Cancer Soc"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7040897"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-7372(93)90010-O"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000279"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366466"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21847"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0547-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23614"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaa034"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2014.02.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11882"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25691"},{"key":"e_1_2_9_16_1","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) | Protocol Development | CTEP. 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