{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:10Z","timestamp":1790776630651,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008667","name":"National Cancer Research Institute","doi-asserted-by":"publisher","award":["UM1 CA173642"],"award-info":[{"award-number":["UM1 CA173642"]}],"id":[{"id":"10.13039\/100008667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many of the 3.8\u00a0million breast cancer survivors in the United States experience long\u2010term side effects of cancer therapy including peripheral neuropathy (PN). We assessed the prevalence and predictors of PN among women with breast cancer followed in the Women's Health Initiative's Life and Longevity After Cancer survivorship cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population included 2420 women with local (79%) or regional (21%) stage disease. Presence of PN was based on the reports of \u201cnerve problems and\/or tingling sensations\u201d after treatment and PN severity was assessed using the Functional Assessment of Cancer Therapy\u2010Gynecologic Oncology Group\/Neurotoxicity instrument. Logistic regression analysis was used to evaluate the socio\u2010demographic and clinical factors associated with PN prevalence and severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial breast cancer treatment included surgery\u2010only (21%), surgery and radiation (53%), or surgery and chemotherapy (\u00b1radiation) (26%). Overall, 17% of women reported PN occurring within days (30%), months (46%), or years (24%) after treatment and 74% reported ongoing symptoms at a median of 6.5\u00a0years since diagnosis. PN was reported by a larger proportion of chemotherapy recipients (33%) compared to those who had surgery alone (12%) or surgery+radiation (11%) (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001). PN was reported more commonly by women treated with paclitaxel (52%) and docetaxel (39%), versus other chemotherapy (17%) (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001). In multivariable analyses, treatment type (chemotherapy vs. none; OR, 95% CI: 3.31, 2.4\u20134.6), chemotherapy type (taxane vs. no\u2010taxane; 4.74, 3.1\u20137.3), and taxane type (paclitaxel vs. docetaxel; 1.59, 1.0\u20132.5) were associated with higher odds of PN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PN is an important long\u2010term consequence of taxane\u2010based chemotherapy in breast cancer survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4202","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T08:56:07Z","timestamp":1628931367000},"page":"6666-6676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Prevalence and predictors of peripheral neuropathy after breast cancer treatment"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-2712","authenticated-orcid":false,"given":"Mandana","family":"Kamgar","sequence":"first","affiliation":[{"name":"Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-7321","authenticated-orcid":false,"given":"Mark K.","family":"Greenwald","sequence":"additional","affiliation":[{"name":"Barbara Ann Karmanos Cancer Institute Wayne State University Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-0199","authenticated-orcid":false,"given":"Hadeel","family":"Assad","sequence":"additional","affiliation":[{"name":"Barbara Ann Karmanos Cancer Institute Wayne State University Detroit Michigan 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