{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:45:43Z","timestamp":1790019943155,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["Dr. Jindra Pavel was supported by AZV NV18\u201003\u20100027"],"award-info":[{"award-number":["Dr. Jindra Pavel was supported by AZV NV18\u201003\u20100027"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Nucleophosmin<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> (<jats:italic>NPM1<\/jats:italic>) mutations in acute myeloid leukemia (AML) confer a survival advantage in the absence of <jats:italic>FLT3<\/jats:italic>\u2010internal tandem duplication (<jats:italic>FLT3<\/jats:italic>\u2010ITD). Here, we investigated the main predictors of outcome after allogeneic hematopoietic stem cell transplantation (allo\u2010HCT). We identified 1572 adult (age \u2265\u00a018\u00a0year) patients with <jats:italic>NPM1<\/jats:italic>\u2010mutated AML in first complete remission (CR1:78%) or second complete remission (CR2:22%) who were transplanted from matched sibling donors (30.8%) or unrelated donors (57.4%) between 2007 and 2019 at EBMT participating centers. Median follow\u2010up for survivors was 23.7\u00a0months. <jats:italic>FLT3<\/jats:italic>\u2010ITD was present in 69.3% of patients and 39.2% had detectable minimal\/measurable residual disease (MRD) at transplant. In multivariate analysis, relapse incidence (RI) and leukemia\u2010free survival (LFS) were negatively affected by concomitant <jats:italic>FLT3<\/jats:italic>\u2010ITD mutation (HR 1.66 <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001, and HR 1.53, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001, respectively), MRD positivity at transplant (HR 2.18, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22125<\/jats:sup> and HR 1.71, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22125<\/jats:sup>, respectively), and transplant in CR2 (HR 1.36, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.026, and HR 1.26, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.033, respectively), but positively affected by Karnofsky score \u226590 (HR 0.74, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012, and HR 0.7, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0002, respectively). Overall survival (OS) was also negatively influenced by concomitant <jats:italic>FLT3<\/jats:italic>\u2010ITD (HR 1.6, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001), MRD positivity at transplant (HR 1.61, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22125<\/jats:sup>), and older age (HR 1.22 per 10\u00a0years, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), but positively affected by matched sibling donor (unrelated donor: HR 1.35, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012; haploidentical donor: HR 1.45, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037) and Karnofsky score \u226590 (HR 0.73, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). These results highlight the independent and significant role of <jats:italic>FLT3<\/jats:italic>\u2010ITD, MRD status, and disease status on posttransplant outcomes in patients with <jats:italic>NPM1<\/jats:italic>\u2010mutated AML allowing physicians to identify patients at risk of relapse who may benefit from posttransplant prophylactic interventions.<\/jats:p>","DOI":"10.1002\/cam4.4218","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T09:46:44Z","timestamp":1642672004000},"page":"1068-1080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Measurable residual disease, FLT3\u2010ITD mutation, and disease status have independent prognostic influence on outcome of allogeneic stem cell transplantation in NPM1\u2010mutated acute myeloid leukemia"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-0224","authenticated-orcid":false,"given":"Rama","family":"Al Hamed","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Jacobi Medical Center\/Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Department of Hematology EBMT Paris Office CEREST\u2010TC Saint Antoine Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Daguindau","sequence":"additional","affiliation":[{"name":"H\u00f4pital Jean Minjoz Service d`H\u00e9matologie  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Niittyvuopio","sequence":"additional","affiliation":[{"name":"HUCH Comprehensive Cancer Center Stem Cell Transplantation Unit  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Huynh","sequence":"additional","affiliation":[{"name":"CHU \u2010 Institut Universitaire du Cancer Toulouse  Oncopole, Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hematology \u2013 BMT H\u00f4pital St. Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha","family":"Srour","sequence":"additional","affiliation":[{"name":"CHU de Lille Universit\u00e9 de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Henri Bourhis","sequence":"additional","affiliation":[{"name":"Department of Hematology Gustave Roussy Cancer Campus BMT Service  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"University Hospital Eppendorf Bone Marrow Transplantation Centre  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Tholouli","sequence":"additional","affiliation":[{"name":"Clinica Haematology Department Manchester Royal Infirmary  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goda","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen (UMCG) University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Poir\u00e9","sequence":"additional","affiliation":[{"name":"Department of Haematology Cliniques Universitaires St. Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Martin","sequence":"additional","affiliation":[{"name":"Goethe\u2010Universitaet Medizinische Klinik II H\u00e4matologie, Medizinische Onkologie  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Th\u00e9r\u00e8se","family":"Rubio","sequence":"additional","affiliation":[{"name":"CHRU BRABOIS Service H\u00e9matologie  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Jindra","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Charles University Hospital  Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de Transplantation &amp; Therapie Cellulaire Centre de Recherche en Canc\u00e9rologie de Marseille  Marseille 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909303411407"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-254441"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1885"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-012252"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-299990"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2168"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-604496"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2248"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-733196"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.135681"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-651562"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507471"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-461749"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2991\/chi.d.191207.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.230"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.305"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041974"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002959"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.3826"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.5323"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-01005-y"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.243410"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.251"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.105"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.211615"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2014.12.005"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30680"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.04.004"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620719882666"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.02.003"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16722"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T06:24:26Z","timestamp":1693117466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/cam4.4218"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4218","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]},"assertion":[{"value":"2021-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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