{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:53:51Z","timestamp":1772585631602,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We explored the impact of clinically significant portal hypertension (CSPH) on short\u2010 and long\u2010term outcomes of intrahepatic cholangiocarcinoma (ICC) after liver resection (LR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of 352 ICC patients with cirrhosis who underwent LR were extracted from the Primary Liver Cancer Big Data (PLCBD) between 2005 and 2015 and reviewed. A nomogram based on logistic analyses was developed to illustrate the influencing factors of post\u2010hepatectomy liver failure (PHLF). The impact of CSPH on long\u2010term survival was explored through propensity score matching (PSM) analysis, log\u2010rank test, Cox proportional hazards model, and Kaplan\u2013Meier curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 106 patients had CSPH, and 246 patients did not. A nomogram established based on GGT level, CSPH, intraoperative blood loss, and multiple tumors had an area under the receiver operating characteristic curve of 0.721 (95% confidence interval [CI]\u00a0=\u00a00.630\u20130.812), which displayed a better PHLF predictive value than the MELD score (0.639, 95% CI\u00a0=\u00a00.532\u20130.747) and Child\u2013Pugh score (0.612, 95% CI\u00a0=\u00a00.506\u20130.719). Moreover, the patients with CSPH had worse overall survival (OS) rates than the patients without CSPH in the whole cohort (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.011) and PSM cohort (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.017). After PSM, multivariable Cox analyses identified that CSPH was an independent risk factor for OS (hazard ratio\u00a0=\u00a01.585, 95% CI\u00a0=\u00a01.107\u20132.269; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CSPH is a significant risk factor for PHLF and OS in ICC patients with cirrhosis after surgery. Selecting the proper patients before operation can effectively avoid PHLF and improve the prognosis of ICC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4222","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T08:33:23Z","timestamp":1629275603000},"page":"6985-6997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of portal hypertension on short\u2010 and long\u2010term outcomes after liver resection for intrahepatic cholangiocarcinoma: A propensity score matching analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-3855","authenticated-orcid":false,"given":"Jun","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou China"},{"name":"The Big Data Institute of Southeast Hepatobiliary Health Information Fuzhou 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