{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:02:31Z","timestamp":1767963751134,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:00:00Z","timestamp":1422489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FilGAP<\/jats:styled-content>, a Rho GTPase\u2010activating protein (<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>), acts as a mediator of Rho\/ROCK (Rho\u2010associated protein kinase)\u2010dependent amoeboid movement, and its knockdown results in Rac\u2010driven mesenchymal morphology. Herein, we focus on the possible roles of <jats:styled-content style=\"fixed-case\">FilGAP<\/jats:styled-content> expression in normal and malignant lymphocytes. Eighty\u2010three cases of follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>), 84 of diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>), and 25 of peripheral T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>), as well as 10 of normal lymph nodes, were immunohistochemically investigated. In normal lymph nodes, <jats:styled-content style=\"fixed-case\">FilGAP<\/jats:styled-content> immunoreactivity was significantly higher in lymphocytes in the mantle zone as compared to those in the germinal center and paracortical areas. In contrast, the expression levels of both cytoplasmic and perinuclear Rac1 were significantly lower in the germinal center as compared to paracortical regions, suggesting that changes in the <jats:styled-content style=\"fixed-case\">FilGAP<\/jats:styled-content>\/Rac axis may occur in B\u2010cell lineages. In malignant lymphomas, <jats:styled-content style=\"fixed-case\">FilGAP<\/jats:styled-content> expression was significantly higher in B\u2010cell lymphomas than <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>, and the immunohistochemical scores were positively correlated with cytoplasmic Rac1 scores in <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, but not in <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>. Patients with <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> and germinal center B\u2010cell\u2010like (<jats:styled-content style=\"fixed-case\">GCB<\/jats:styled-content>)\u2010type DLBCL showing high <jats:styled-content style=\"fixed-case\">FilGAP<\/jats:styled-content> scores had poor overall survival rates as compared to the low\u2010score patients. Moreover, multivariate <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox regression analysis showed that a high <jats:styled-content style=\"fixed-case\">FilGAP<\/jats:styled-content> score was a significant and independent unfavorable prognostic factor in <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>, but not in <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>. In conclusion, <jats:styled-content style=\"fixed-case\">FilGAP<\/jats:styled-content> may contribute to change in cell motility of B\u2010lymphocytes. In addition, its expression appears to be useful for predicting the behavior of B\u2010cell lymphoma, in particular <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.423","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T03:54:53Z","timestamp":1422590093000},"page":"808-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["FilGAP, a Rac\u2010specific Rho GTPase\u2010activating protein, is a novel prognostic factor for follicular lymphoma"],"prefix":"10.1002","volume":"4","author":[{"given":"Tatsuya","family":"Nishi","sequence":"first","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine 1\u201015\u20101 Kitasato Minami\u2010ku Sagamihara Kanagawa 252\u20100374 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine 1\u201015\u20101 Kitasato Minami\u2010ku Sagamihara Kanagawa 252\u20100374 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Hashimura","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine 1\u201015\u20101 Kitasato Minami\u2010ku Sagamihara Kanagawa 252\u20100374 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine 1\u201015\u20101 Kitasato Minami\u2010ku Sagamihara Kanagawa 252\u20100374 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Ohta","sequence":"additional","affiliation":[{"name":"Division of Cell Biology Department of Biosciences Kitasato University School of Science 1\u201015\u20101 Kitasato Minami\u2010ku Sagamihara Kanagawa 252\u20100374 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Saegusa","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine 1\u201015\u20101 Kitasato Minami\u2010ku Sagamihara Kanagawa 252\u20100374 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,29]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO classification of tumours, tumours of haematopoietic and lymphoid tissues","author":"Swerdlow S. 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