{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:37:27Z","timestamp":1791405447179,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602668"],"award-info":[{"award-number":["81602668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8197110875"],"award-info":[{"award-number":["8197110875"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ductal carcinoma in situ with microinvasion (DCISM) represents ~1% of all breast cancer cases and is arguably a more aggressive subtype of ductal carcinoma in situ (DCIS). Lacking studies with a large population, the survival outcomes of DCISM are still poorly understood and the treatment recommendations remain controversial. This study aims to investigate the long\u2010term outcome of patients with DCISM, potential risk factors for their prognosis, and the difference of survival between patients treated with breast\u2010conserving surgery plus radiotherapy (BCT\u00a0+\u00a0RT) and mastectomy only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 1299 patients from 2008 to 2019 with DCISM were retrospectively retrieved. Clinicopathological features were analyzed. Subgroup analysis was conducted between patients who underwent BCT\u00a0+\u00a0RT and mastectomy only. Univariate and multivariate analyses were performed to identify prognostic factors for survival. Differences of survival between two groups were compared using the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Totally, 1286 patients had follow\u2010up information, the median follow\u2010up is 54.57\u00a0months, the 5\u2010year local\u2013regional\u2010free survival (LRFS), distant metastasis\u2010free survival (DMFS), and overall survival (OS) were 98.6%, 97.1%, and 99.4%, respectively, two deaths were due to breast cancer. Multivariate analysis identified age &lt;40 (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.028) and close margin (\u22642\u00a0mm) as independent negative prognostic factors for LRFS. No prognostic factors were identified for DMFS and OS. The 5\u2010year LRFS, DMFS, and OS of patients who had DCIS component \u22655\u00a0cm and underwent mastectomy without adjuvant radiotherapy were 100%, 98.4%, and 98.4%, respectively. After propensity score matching (PSM), no survival difference was observed between patients treated with BCT\u00a0+\u00a0RT or mastectomy only.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DCISM patients had a good survival, even those with DCIS component \u22655\u00a0cm. Patients aged &lt;40 or with close margin (\u22642\u00a0mm) had a poorer LRFS, but not DMFS or OS. BCT\u00a0+\u00a0RT is a feasible choice for DCISM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.4263","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T14:52:48Z","timestamp":1632235968000},"page":"7203-7212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Characteristics, prognosis, risk factors, and management of recently diagnosed ductal carcinoma in situ with microinvasion"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9499-3047","authenticated-orcid":false,"given":"Chunyan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Shanghai Medical College Fudan University Shanghai 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