{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:46:18Z","timestamp":1785228378199,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to explore the efficacy and safety of mirabegron in treating irritative symptoms induced by intravesical immunotherapy with Bacillus Calmette\u2013Guerin (BCG) after transurethral resection of bladder tumors (TURBT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 160 patients subjected to TURBT was randomly divided into the mirabegron group and placebo group with 80 patients in each group. Then, the patients were administered 25\u00a0mg mirabegron or placebo daily, starting the first day after BCG infusion. The first BCG perfusion was conducted at least 2\u00a0weeks after TURBT. The 3\u2010day bladder diaries were completed in all patients, 1\u00a0day before BCG perfusion, and on the 1st, 6th, and 13th days after the first BCG perfusion. Overactive bladder symptom scores were completed 1\u00a0day before BCG perfusion, and on the 6th and 13th days after the first BCG perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptom scores of bladder hyperactivity were significantly different between the two groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Also, the frequency of nocturia, pollakiuria, micturition urgency, urinary incontinence and was significantly lower in group 1 than that in group two (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings demonstrate that mirabegron is a valuable clinical drug for the management of irritative symptoms after TURBT with subsequent intravesical BCG perfusion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4278","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T17:43:44Z","timestamp":1632246224000},"page":"7534-7541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mirabegron improves the irritative symptoms caused by BCG immunotherapy after transurethral resection of bladder 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