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Optimal BC treatment strategies in this population are yet unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BC subtypes and treatment were retrospectively investigated between December 2016 and January 2019 in a multicentre study. BC risks were evaluated according to the type of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five women of our study population (35\/44; 79.5%) had developed 36 breast lesions at first diagnosis at a mean age of 34\u00a0years. Those breast lesions comprised 32 invasive BCs (89%), three ductal carcinoma in situ alone (8%) and one malignant phyllodes tumour (3%). BCs were mainly high\u2010grade (18\/32), of no special type (NST; 31\/32), HER2\u2010enriched (11\/32) or luminal\u2010B\u2010(like)\u2010type (10\/32). Affected women (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) received breast\u2010conserving surgery (BCS, <jats:italic>n<\/jats:italic>\u00a0=\u00a017) or a mastectomy (ME, <jats:italic>n<\/jats:italic>\u00a0=\u00a018) including seven women with simultaneous contralateral prophylactic mastectomy (CPM) at first diagnosis. Nineteen women suffered 20 breast or locoregional axillary lesions at second diagnosis with mean age of 36. Median time between first and second diagnosis was 57\u00a0months; median time to contra\u2010 and ipsilateral recurrence depended on surgical strategies (BCS: 46 vs. unilateral ME: 93 vs. bilateral ME\u00a0&gt;\u00a0140\u00a0months). Women with a primary treatment of solitaire therapeutic ME suffered from contralateral BC earlier compared to those with therapeutic ME and CPM (median: 93 vs. &gt;140\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aggressive BC subtypes occur among women with LFS. Surgical treatment, i.e. ME and CPM, may prolong time to a second BC diagnosis. Conclusion on long\u2010term survival benefit is pending. Individual competing tumour risks and long\u2010term outcomes need to be taken into consideration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4300","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T15:40:27Z","timestamp":1632757227000},"page":"7747-7758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Breast cancer characteristics and surgery among women with Li\u2010Fraumeni syndrome in Germany\u2014A retrospective cohort study"],"prefix":"10.1002","volume":"10","author":[{"given":"Nathalie","family":"Rippinger","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Fischer","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Hospital Heidelberg Heidelberg 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