{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:38:27Z","timestamp":1747147107261,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with very\u2010high\u2010risk prostate cancer (VHRPCa) have earlier biochemical recurrences (BCRs) and higher mortality rates. It remains unknown whether extended robot\u2010assisted laparoscopic prostatectomy (eRALP) without neoadjuvant or adjuvant therapy can improve the outcomes of VHRPCa patients. We aimed to determine the feasibility and efficacy of eRALP as a form of monotherapy for VHRPCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 76 men who were treated with eRALP without neoadjuvant\/adjuvant therapy were analyzed. eRALP was performed using an extrafascial approach. Extended pelvic lymph node (LN) dissection (ePLND) included nodes above the external iliac axis, in the obturator fossa, and around the internal iliac artery up to the ureter. The outcome measures were BCR, treatment failure (defined as when the prostate\u2010specific antigen level did not decrease to &lt;0.1\u00a0ng\/ml postoperatively), and urinary continence (UC). Kaplan\u2013Meier, logistic regression, and Cox proportional\u2010hazards model were used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median operative time was 246\u00a0min, and median blood loss was 50\u00a0ml. Twenty\u2010one patients experienced postoperative complications. Median follow\u2010up was 25.2\u00a0months; 19.7% of patients had treatment failure. Three\u2010year, BCR\u2010free survival rate was 62.0%. Castration\u2010resistant prostate cancer\u2010free survival rate was 86.1%. Overall survival was 100%. In 55 patients who had complete postoperative UC data, 47 patients (85.5%) recovered from their UC within 12\u00a0months. Clinical stage cT3b was an independent preoperative treatment failure predictor (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.035), and node positivity was an independent BCR predictor (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.037). The small sample size and retrospective nature limited the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This approach was safe and produced acceptable UC\u2010recovery rates. Preoperative seminal vesicle invasion is associated with treatment failure, and pathological LN metastases are associated with BCR. Therefore, our results may help informed decisions about neoadjuvant or adjuvant therapies in VHRPCa cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Precis<\/jats:title><jats:p>Extended robot\u2010assisted laparoscopic prostatectomy and extended pelvic lymph node dissection without adjuvant therapy is safe and effective for some patients with very\u2010high\u2010risk prostate cancer. The clinical stage and node positivity status predicted monotherapy failure, which may indicate good adjuvant therapy candidate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4308","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T12:44:56Z","timestamp":1632573896000},"page":"7968-7976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extended robot\u2010assisted laparoscopic prostatectomy and extended pelvic lymph node dissection as a monotherapy in patients with very high\u2010risk prostate cancer Patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2229-0948","authenticated-orcid":false,"given":"Noriyoshi","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Funaki","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Kakuda","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanae","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terutaka","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahiko","family":"Kikugawa","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Saika","sequence":"additional","affiliation":[{"name":"Department of Urology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"volume-title":"NCCN guidelines on prostate cancer, version3.2020","year":"2020","author":"National Comprehensive Cancer Network","key":"e_1_2_11_2_1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.02.070"},{"volume-title":"Prostate guidelines. 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