{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:52:11Z","timestamp":1767909131138,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The safety of weekly regional hyperthermia performed with 8\u00a0MHz radiofrequency (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>) capacitive heating equipment has been established in rectal cancer. We aimed to standardize hyperthermia treatment for scientific evaluation and for assessing local tumor response to <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> hyperthermia in rectal cancer. Forty\u2010nine patients diagnosed with rectal adenocarcinoma were included in the study. All patients received chemoradiation with intensity\u2010modulated radiation therapy 5\u00a0days\/week (dose, 50\u00a0Gy\/25 times) concomitant with 5\u00a0days\/week for five times of capecitabine (1700\u00a0mg\/m<jats:sup>2<\/jats:sup> per day) and once a week for five times of 50\u00a0min irradiations by an 8\u00a0MHz <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> capacitive heating device. Thirty\u2010three patients underwent surgery 8\u00a0weeks after treatment. Three patients did not undergo surgery because of progressive disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) and 13 refused. Eight (16.3%) patients had a pathological complete response (<jats:styled-content style=\"fixed-case\">ypCR<\/jats:styled-content>) after surgery. Among patients without surgery, 3 (6.1%) had clinical complete response (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) and 3 (6.1%) had local <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> but distant <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CRPD<\/jats:styled-content>). Ninety percent of <jats:styled-content style=\"fixed-case\">ypCR<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> patients were shown in 6.21\u00a0W\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a0m<jats:sup>\u22122<\/jats:sup>\/treatment or higher group of average total accumulated irradiation output with 429\u00b0C\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a0m<jats:sup>\u22122<\/jats:sup> or higher group of total accumulated thermal output. However, a patient with <jats:styled-content style=\"fixed-case\">CRPD<\/jats:styled-content> was in the higher total accumulated thermal output group. We propose a new quantitative parameter for the hyperthermia and demonstrated that patients can benefit from mild irradiation with mild temperature. Using these parameters, the exact output, optimal thermal treatment, and contraindications or indications of this modality could be determined in a multi\u2010institutional, future study.<\/jats:p>","DOI":"10.1002\/cam4.431","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T08:57:56Z","timestamp":1423472276000},"page":"834-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study"],"prefix":"10.1002","volume":"4","author":[{"given":"Hisanori","family":"Shoji","sequence":"first","affiliation":[{"name":"Division of Surgery Hidaka Hospital Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Motegi","sequence":"additional","affiliation":[{"name":"Division of Surgery Hidaka Hospital Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Osawa","sequence":"additional","affiliation":[{"name":"Division of Surgery Hidaka Hospital Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Okonogi","sequence":"additional","affiliation":[{"name":"Division of Radiology Hidaka Hospital Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Division of Radiology Hidaka Hospital Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Andou","sequence":"additional","affiliation":[{"name":"Division of Surgery Hidaka Hospital Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Asao","sequence":"additional","affiliation":[{"name":"Department of Oncology Clinical Development Graduate School of Medicine Gunma University Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science Graduate School of Medicine Gunma University Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoji","family":"Ogoshi","sequence":"additional","affiliation":[{"name":"Division of Cancer Diagnosis and Cancer Treatment Hidaka Hospital Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060829"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7629"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70599-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"Roussakow S..2013.The history of hyperthermia rise and\u00a0decline. P. 40inConference Papers in Medicine. Volume 2013 Article ID 428027. Available athttp:\/\/dx.doi.org\/10.1155\/2013\/428027\/(accessed 24 January 2015).","DOI":"10.1155\/2013\/428027"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"Roussakow S.2013.Critical analysis of randomized trials on hyperthermia: dubious effect and multiple biases. P. 31inConference Papers in Medicine. Volume 2013. Article ID 412186. 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