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However, the evidence for decision\u2010making is lacking in terms of comparison between HA and HATACE. Herein, a comprehensive evaluation was performed to compare the efficacy and safety of HATACE with monotherapy.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Worldwide studies were collected to evaluate the HATACE regimen for HCC due to the practical need for global extrapolation of applicative population. Meta\u2010analyses were performed using the RevMan 5.3 software (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark).<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010six studies involving a large sample of 5036 patients were included finally. Compared with HA alone, HATACE produced the advantage of 5\u2010year overall survival (OS) rate (OR:1.90; 95%CI:1.46,2.46; p\u00a0<\/jats:italic><\u00a00.05) without increasing toxicity (p\u00a0<\/jats:italic>\u2265\u00a00.05). Compared with TACE alone, HATACE was associated with superior 5\u2010year OS rate (OR:3.54; 95%CI:1.96,6.37; p\u00a0<\/jats:italic><\u00a00.05) and significantly reduced the incidences of severe liver damage (OR:0.32; 95%CI:0.11,0.96; p\u00a0<\/jats:italic><\u00a00.05) and ascites (OR:0.42; 95%CI:0.20,0.88; p\u00a0<\/jats:italic><\u00a00.05). Subgroup analysis results of small (\u22643\u00a0cm) HCC revealed that there were no significant differences between the HATACE group and HA monotherapy group in regard to the OS rates (p<\/jats:italic>\u00a0\u2265\u00a00.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Compared with TACE alone, HATACE was more effective and safe for HCC. Compared with HA alone, HATACE was more effective for non\u2010small\u2010sized (>3\u00a0cm) HCC with comparable safety. However, the survival benefit of adjuvant TACE in HATACE regimen was not found for the patients with small (\u22643\u00a0cm) HCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4350","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T20:04:11Z","timestamp":1634760251000},"page":"8432-8450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hyperthermia ablation combined with transarterial chemoembolization versus monotherapy for hepatocellular carcinoma: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-0318","authenticated-orcid":false,"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Modern Physics Chinese Academy of Sciences Lanzhou China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences Lanzhou 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