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We aimed to retrospectively evaluate the morbidity and hazard elements of sPGF after allo\u2010HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight hundred and sixty\u2010three patients who achieved initial engraftment of both neutrophils and platelets were retrospectively reviewed in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two patients developed sPGF within 180\u00a0days post\u2010transplants, with the median onset time was 62\u00a0days (range, 34\u2013121\u00a0days) post\u2010transplants. The overall cumulative incidence of sPGF within 180\u00a0days post\u2010transplantation was 6.0%, with 3.4%, 3.4%, and 10.1%, respectively, in matched sibling donor (MSD), matched unrelated donor (MUD), and haploidentical donor (HID) transplant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Multivariable analysis showed that HID (HID vs. MSD: hazard ratio [HR] 2.525, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004; HID vs. MUD: [HR] 3.531, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017), acute graft versus host disease (aGVHD) within +30\u00a0days ([HR] 2.323, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), and cytomegalovirus (CMV) reactivation ([HR] 8.915, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) within +30\u00a0days post\u2010transplants were hazard elements of sPGF. The patients with sPGF had poorer survival than good graft function (51.7\u00b18.1% vs. 62.9\u00b11.9%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Our results also showed that only CMV reactivation was the hazard element for the development of PGF in HID transplant ([HR] 12.521 <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HID transplant is also an independent hazard element of sPGF except for aGVHD and CMV reactivation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4353","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T12:24:46Z","timestamp":1634819086000},"page":"8497-8506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single\u2010center retrospective study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-5053","authenticated-orcid":false,"given":"Wei\u2010Ran","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Ping","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University Guangzhou 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