{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:16:09Z","timestamp":1764494169173,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is paucity of data regarding clinical characteristics, laboratory parameters and outcomes of coronavirus disease (COVID\u201019) in cancer versus non\u2010cancer patients, particularly from India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was an observational, single\u2010centre, retrospective analysis of patients with laboratory\u2010confirmed COVID\u201019\u00a0hospitalised in our institution between 22\u00a0May 2020 and 1 December 2020. We compared baseline clinical characteristics, laboratory parameters and outcomes of COVID\u201019 (overall mortality, time to discharge) between cancer and non\u2010cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 200 COVID\u201019 infection episodes were analysed of which 109 (54.5%) were patients with cancer and 91 (45.5%) were patients without cancer. The median age was 43 (interquartile range [IQR]:32\u201357), 51 (IQR: 33\u201362) and 38 (IQR: 31.5\u201349.3)\u00a0years; of whole cohort, cancer and non\u2010cancer patients, respectively. Comparison of outcomes showed that oxygen requirement (31.2% [95% CI: 22.6\u201340.7] vs. 17.6% [95% CI: 10.4\u201326.9]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), median time to discharge (11\u00a0days [IQR: 6.75\u201316] vs. 6\u00a0days [IQR: 3\u20139.75]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and mortality (10.0% [95% CI: 5.2\u201317.3] vs. 1.1% [95% CI: 0.03\u20135.9]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017) were significantly higher in patients with cancer. In univariable analysis, factors associated with higher mortality in the whole cohort included diagnosis of cancer (10.1% vs. 1.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027; odds ratio [OR]: 7.04), age \u226560 (17.4% vs. 2.6%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001; OR: 7.38), oxygen requirement (22% vs. 0.6%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; OR: 29.01), chest infiltrates (19.2% vs. 1.4%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; OR: 22.65), baseline absolute lymphocyte count &lt;1\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L (10.8% vs. 1.9%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.023; OR:5.1), C\u2010reactive protein &gt;1\u00a0mg% (12.8% vs. 0%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027; OR: 24.69), serum procalcitonin &gt;0.05\u00a0ng\/ml (22.65% vs. 0%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004; OR: 4.49) and interleukin\u20106 &gt;6\u00a0pg\/ml (10.8% vs. 1.3%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.036; OR: 3.08). In multivariable logistic regression, factors significantly associated with mortality were oxygen requirement (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005; OR: 13.11) and high baseline procalcitonin level (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.014; OR: 37.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cancer patients with COVID\u201019\u00a0have higher mortality and require longer hospital stay. High procalcitonin levels and oxygen requirement during admission are other factors that affect outcomes adversely.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4379","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T07:59:02Z","timestamp":1637135942000},"page":"8777-8788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics, laboratory parameters and outcomes of COVID\u201019 in cancer and non\u2010cancer patients from a tertiary Cancer Centre in India"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-2207","authenticated-orcid":false,"given":"Sumeet P.","family":"Mirgh","sequence":"first","affiliation":[{"name":"BMT Unit Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"},{"name":"Homi Bhabha National Institute Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anant","family":"Gokarn","sequence":"additional","affiliation":[{"name":"BMT Unit Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"},{"name":"Homi Bhabha National Institute Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhil","family":"Rajendra","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini","family":"More","sequence":"additional","affiliation":[{"name":"Department of Medicine ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujit","family":"Kamtalwar","sequence":"additional","affiliation":[{"name":"Department of Medicine ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kritika S.","family":"Katti","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuj","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasu Babu","family":"Goli","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Ravind","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravikrishna","family":"Madala","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Kakoti","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyamvada","family":"Maitre","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Punatar","sequence":"additional","affiliation":[{"name":"BMT Unit Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"},{"name":"Homi Bhabha National Institute Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akanksha","family":"Chichra","sequence":"additional","affiliation":[{"name":"BMT Unit Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"},{"name":"Homi Bhabha National Institute Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Medicine ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhakti","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Department of Anaesthesiology, Pain and Critical Care Medicine ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Joshi","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Patkar","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Hematopathology Lab Department of Pathology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Tembhare","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Hematopathology Lab Department of Pathology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Twinkle","family":"Khanka","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Hematopathology Lab Department of Pathology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sweta","family":"Rajpal","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Hematopathology Lab Department of Pathology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Hematopathology Lab Department of Pathology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhana","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.G.","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Hematopathology Lab Department of Pathology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedang","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Shetty","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Department of Radiodiagnosis ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeti","family":"Chavan","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"OIC Composite Lab Department of Laboratory Medicine ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Bhat","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Department of Microbiology ACTREC \u2013 Tata Memorial Centre ACTREC Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Nair","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Department of Surgical Oncology ACTREC \u2013 Tata Memorial Centre ACTREC Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-6472","authenticated-orcid":false,"given":"Navin","family":"Khattry","sequence":"additional","affiliation":[{"name":"BMT Unit Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"},{"name":"Homi Bhabha National Institute Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudeep","family":"Gupta","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Mumbai India"},{"name":"Department of Medical Oncology ACTREC \u2013 Tata Memorial Centre Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13091"},{"volume-title":"WHO coronavirus disease (COVID\u201019) dashboard","year":"2020","key":"e_1_2_10_3_1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30096-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.03.296"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01580"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2020.1831113"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.10599"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2020.102525"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3423"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015301"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31042-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107018"},{"key":"e_1_2_10_16_1","unstructured":"Ministry of Health & Family Welfare.Clinical management protocol: COVID\u201019 version 2 [Internet]. Mohfw.gov.in (web archive link 08 May 2020). Accessed May 23 2021.https:\/\/www.mohfw.gov.in\/pdf\/ReviseddischargePolicyforCOVID19.pdf"},{"key":"e_1_2_10_17_1","unstructured":"BlancB FinchCA HallbergL et al.Nutritional anaemias. Report of a WHO Scientific Group. WHO Technical Report Series1968;1\u201040."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1788_20"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04328-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31187-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31173-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25972"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.08.013"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.20.00225"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3460"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.20.00444"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0516"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:02:24Z","timestamp":1693198944000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":26,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/cam4.4379"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4379","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2021,11,16]]},"assertion":[{"value":"2021-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}