{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:57:57Z","timestamp":1792292277143,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anal squamous cell carcinoma (ASCC) is a rare malignant tumor with increasing incidence. The goal of our study was to analyze the treatment outcome and prognostic factors of ASCC in South China in the past half\u2010century.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively included 59 patients with ASCC admitted from 1975 to 2018 in Sun Yat\u2010sen University cancer center. The clinical records and follow\u2010up information of all patients were collected. Survival analysis and univariate and multivariate regression analyses were performed using the \u201csurvival\u201d and \u201csurvminer\u201d packages of R software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 59 patients, 5 patients had distant metastasis at diagnosis. Among 54\u00a0M0\u00a0stage patients, 33 patients received chemoradiotherapy (CRT), 19 patients received local surgery, and 2 patients refused curative treatment and received the best supportive treatment (BST). The most common grade 3\u20134 acute toxicities during treatment were myelosuppression and radiation dermatitis. The median follow\u2010up time was 32\u00a0months. For the whole group, the 3\u2010year and 5\u2010year overall survival (OS) rates and disease\u2010free survival (DFS) were 71.1% and 63.6%, and 73.4% and 69.0%, respectively. Multivariate regression analysis showed that the T3\u20134\u00a0stage was an independent prognostic risk factor for OS, progression\u2010free survival (PFS), and DFS. And M1 was an independent prognostic risk factor for PFS and DFS. Patients in stage M0\u00a0mainly treated with CRT had better local control than those mainly treated with surgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027). For M0 patients, induction chemotherapy combined with CRT tends to prolong OS compared with CRT alone (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.26). The 3\u2010year colostomy\u2010free survival for the whole group was 81.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CRT is recommended as the first choice for the treatment of M0\u00a0stage ASCC. Induction chemotherapy may bring better survival benefits for some patients. Patients with ASCC in China seem to have a better local control rate, which suggested different treatment strategies may be needed in China.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4433","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T08:58:53Z","timestamp":1637744333000},"page":"117-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive treatment experience of anal squamous cell carcinoma from a tertiary cancer center in South China"],"prefix":"10.1002","volume":"11","author":[{"given":"Yan","family":"Yuan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou PR China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Hao","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou PR China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou PR China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-5101","authenticated-orcid":false,"given":"Hui","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou PR China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Fan","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou PR China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-5376","authenticated-orcid":false,"given":"Yuan\u2010Hong","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou PR China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao\u2010Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou PR China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9922-640X","authenticated-orcid":false,"given":"Wei\u2010Wei","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou PR China"},{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24215"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001307"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30653-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.06.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.398"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02586980"},{"key":"e_1_2_10_10_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines:Anal Carcinoma).2020."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.2040"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605605"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03266"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03409-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092180"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07170-z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"issue":"1","key":"e_1_2_10_18_1","first-page":"1","article-title":"Human papillomavirus (HPV) prevalence and HPV type distribution in cervical, vulvar, and anal cancers in central and eastern Europe","volume":"22","author":"\u0160kamperle M","year":"2013","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"issue":"10","key":"e_1_2_10_19_1","first-page":"30","article-title":"Gene analysis of human papillomavirus 16\/18 infection in anorectal and colorectal malignancies","volume":"24","author":"Liu W","year":"2011","journal-title":"Chin J Med Postgraduates"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.16.1914"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/10872910252972267"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00499J"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1644"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199706000-00015"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2527"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.8085"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2021.1879250"},{"issue":"1","key":"e_1_2_10_28_1","first-page":"103","article-title":"Malignancies of the anal canal: a multi\u2010center retrospective analysis in South China population","volume":"19","author":"Sun P","year":"2014","journal-title":"J BUON"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.11.057"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70086-X"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.02.042"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.1351"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.034"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21866"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28847"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx029"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30104-3"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2333"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T16:48:43Z","timestamp":1693241323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/cam4.4433"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4433","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"assertion":[{"value":"2021-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}