{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:36:03Z","timestamp":1777113363861,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773266"],"award-info":[{"award-number":["81773266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess the efficacy and safety of intrapleural perfusion with hyperthermic chemotherapy (IPHC) in treating malignant pleural effusion (MPE) compared to normothermic chemoperfusion of the pleural cavity (NCPC), and to investigate the better treatment to control MPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Malignant pleural effusion patients were enrolled in the study and treated with NCPC or IPHC under video\u2010assisted thoracoscopic surgery (VATS). The chest drainage duration, clinical characteristics, and recurrence time of pleural effusion of patients were collected for statistical analysis. The chi\u2010squared test and the Fisher's exact test were applied to compare the distribution differences in categorical variables. Progression\u2010free survival (PFS) was estimated by the Kaplan\u2013Meier method and was compared by the log\u2010rank test. The survival analysis was performed using the Cox proportional hazards method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 37 MPE patients were enrolled in this study. Twenty\u2010seven patients received NCPC and 10 patients received IPHC under VATS. Significant differences were found in pathological types (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.011), chest drainage duration (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005), and remission rate (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009) between two different treatment groups. The chest drainage duration of IPHC under VATS was shorter than the NCPC group (<jats:italic>t<\/jats:italic>\u00a0=\u00a02.969, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). The remission rate of MPE in IPHC group was better than the NCPC one (OR\u00a0=\u00a00.031, 95% CI: 0.002\u20130.507, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015). The result of the Kaplan\u2013Meier method showed that IPHC group could significantly prolong the PFS of patients with MPE compared to NCPC group (log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). Univariate cox regression analysis showed that patients with MPE in the IPHC group presented significant longer PFS than the NCPC group (HR\u00a0=\u00a00.264, 95% CI: 0.098\u20130.713, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009). Multivariate cox regression analysis further verified this conclusion (HR\u00a0=\u00a00.268, 95% CI: 0.096\u20130.753, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to the NCPC, the IPHC under VATS presents a better control effect on MPE, shorter tube placement time, and longer complete remission time. For this reason, we recommend IPHC under VATS as the first\u2010line treatment for patients with MPE those who can tolerate minimally invasive surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4450","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T05:05:20Z","timestamp":1638421520000},"page":"348-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Better effect of intrapleural perfusion with hyperthermic chemotherapy by video\u2010assisted thoracoscopic surgery for malignant pleural effusion treatment compared to normothermic chemoperfusion of the pleural cavity"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-3066","authenticated-orcid":false,"given":"Yejun","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"},{"name":"Shanghai Tangqiao Community Healthcare Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9023-5302","authenticated-orcid":false,"given":"Zhiyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengjun","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengliang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinchuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tongji University School of Medicine Shanghai East Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2017.1340676"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S134126"},{"issue":"6","key":"e_1_2_11_4_1","first-page":"1712","article-title":"Phase I\/pharmacokinetic study of intraperitoneal cisplatin and etoposide [J]","volume":"47","author":"Zimm S","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2935-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01210-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1526-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv039"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-041511"},{"issue":"3","key":"e_1_2_11_10_1","first-page":"301","article-title":"Implementation of hyperthermic intrathoracic chemotherapy (HITHOC) in Germany [J]","volume":"143","author":"Ried M","year":"2018","journal-title":"Zentralbl Chir"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.04.65"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9293(03)00197-X"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.06.04"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.12.015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.14.256"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2015.1119317"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4450","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:45:00Z","timestamp":1693208700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/cam4.4450"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4450","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}