{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:19:34Z","timestamp":1778001574962,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","award":["06\u20102016\u2010129"],"award-info":[{"award-number":["06\u20102016\u2010129"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An open\u2010label single\u2010arm phase 2 study was conducted to evaluate the role of levetiracetam as a sensitizer of concurrent chemoradiotherapy (CCRT) for patients with newly diagnosed glioblastoma. This study aimed to determine the survival benefit of levetiracetam in conjunction with the standard treatment for glioblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Major eligibility requirements included histologically proven glioblastoma in the supratentorial region, patients 18\u00a0years or older, and Eastern Cooperative Oncology Group (ECOG) performance status of 0\u20132. Levetiracetam was given at 1,000\u20132,000\u00a0mg daily in two divided doses during CCRT and adjuvant chemotherapy thereafter. The primary and the secondary endpoints were 6\u2010month progression\u2010free survival (6mo\u2010PFS) and 24\u2010month overall survival (24mo\u2010OS), respectively. Outcomes of the study group were compared to those of an external control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between July 2016 and January 2019, 76 patients were enrolled, and 73 patients were included in the final analysis. The primary and secondary outcomes were improved in the study population compared to the external control (6mo\u2010PFS, 84.9% vs. 72.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038; 24mo\u2010OS, 58.0% vs. 39.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.018), but the differences were less prominent in a propensity score\u2010matched analysis (6mo\u2010PFS, 88.0% vs. 76.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.071; 24mo\u2010OS, 57.1% vs. 38.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.054). In exploratory subgroup analyses, some results suggested that patients with ages under 65\u00a0years or unmethylated MGMT promoter might have a greater survival benefit from the use of levetiracetam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of levetiracetam during CCRT in patients with newly diagnosed glioblastoma may result in improved outcomes, but further investigations are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4454","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T16:48:07Z","timestamp":1638290887000},"page":"371-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Levetiracetam as a sensitizer of concurrent chemoradiotherapy in newly diagnosed glioblastoma: An open\u2010label phase 2 study"],"prefix":"10.1002","volume":"11","author":[{"given":"Kihwan","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Internal Medicine Radiology Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-2752","authenticated-orcid":false,"given":"Junhyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Internal Medicine Radiology Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok\u2010Gu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Severance Hospital Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine  Hwasun Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se\u2010Hyuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Ajou University Hospital Ajou University School of Medicine  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Hyuk","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Korea University Medical Center Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Kil","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Seoul St. Mary\u2019s Hospital The Catholic University of Korea College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Internal Medicine Radiology Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Se","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Internal Medicine Radiology Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Hee","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Severance Hospital Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae\u2010Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Internal Medicine Radiology Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.5403"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(09)70025\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2015.473"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov031"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000365"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.10.JNS12169"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.6563"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab152"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.14791\/btrt.2021.9.e7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3541"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.06.012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6602"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq044"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25705"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010018\u20100626\u20108"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29439"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201067697\u2010w"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225599"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211644"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11050390"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.598266"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822f02e1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not057"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00092"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/987495"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153770"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010013\u20100094\u20106"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos288"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317508325095"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.2560"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:45:42Z","timestamp":1693208742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,30]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/cam4.4454"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4454","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,30]]},"assertion":[{"value":"2021-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}