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Those in the early stage could be treated with <jats:italic>H. pylori<\/jats:italic> eradication therapy, and are classified into a sensitive group and a resistant group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genome\u2010wide miRNA and miRNA expression profiles were obtained from biopsy specimens of gastric DLBCL. MiRNAs and their targets as predictors of responses to <jats:italic>H. pylori<\/jats:italic> eradication therapy were identified through differential expression and pathway enrichment analysis, and further confirmed with transfection experiments in lymphoma cell lines of B\u2010cell origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Genome\u2010wide miRNA and mRNA profiles showed miR\u2010200 was associated with the sensitive group, and that the resistant group had higher levels of miR\u2010155 and lower levels of DEPTOR (an inhibitor of mTOR) than the sensitive group. BJAB cells transfected with miR\u2010155 also had lower DEPTOR and higher mTOR levels. Therefore, miR\u2010155\u2010mediated inhibition of DEPTOR with secondary activation of mTOR was a potential marker for resistance to <jats:italic>H. pylori<\/jats:italic> eradication therapy. In contrast, pathway enrichment analysis showed that Toll\u2010like receptor 5 (TLR5), the receptor for bacterial flagellin, was a potential marker for sensitivity to <jats:italic>H. pylori<\/jats:italic> eradication therapy. In an independent series, stronger expression of pS6K1 (a direct target of mTOR) was associated with the resistant group and morphologic evidence of active gastritis was associated with the sensitive group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings showed that activation of the miR\u2010155\u2010DEPTOR pathway is a marker for resistance to <jats:italic>H. pylori eradication therapy<\/jats:italic>, and that histological evaluation of active gastritis might be used as a surrogate marker to predict responses to <jats:italic>H. pylori<\/jats:italic> eradication therapy in gastric DLBCL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4466","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T11:03:44Z","timestamp":1639652624000},"page":"555-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["miR\u2010155\u2010regulated mTOR and 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