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Abnormally elevated CD38 expression in T\u2010ALL and T\u2010LBL is associated with tumor expansion and disease development, making CD38 a potential target for anti\u2010T\u2010ALL and T\u2010LBL treatment. Isatuximab is a monoclonal antibody that binds to a specific epitope on CD38. The purpose of the study was to assess the efficacy and safety of isatuximab monotherapy in a phase 2, multicenter, one\u2010arm, open\u2010label study in patients with relapsed or refractory T\u2010ALL or T\u2010LBL (Clinical Trials.gov identifier NCT02999633). The primary endpoint was to assess the efficacy of isatuximab by overall response rate (ORR). An interim analysis based on the efficacy and safety of isatuximab in the first 19 patients enrolled was scheduled, however only 14 patients were enrolled in the study. No patient achieved complete response (CR) or CR with incomplete peripheral recovery. Most patients (11 [78.6%]) developed progressive disease and had progressive disease as their best response. A total of 10 (71.4%) patients had treatment emergent adverse events considered treatment\u2010related, with infusion reactions as the most frequent drug\u2010related TEAE, occurring in 8 (57.1%) patients. Despite the low efficacy of isatuximab in the current study, it is likely that the use of immunotherapy medication in T\u2010ALL will be expanded through logically targeted approaches, together with advances in the design of T\u2010cell therapy and clinical experience and will provide restorative options beyond chemotherapy and targeted treatments.<\/jats:p>","DOI":"10.1002\/cam4.4478","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T04:45:55Z","timestamp":1643777155000},"page":"1292-1298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Isatuximab monotherapy in patients with refractory T\u2010acute lymphoblastic leukemia or T\u2010lymphoblastic lymphoma: Phase 2 study"],"prefix":"10.1002","volume":"11","author":[{"given":"Nicolas","family":"Boissel","sequence":"first","affiliation":[{"name":"Department of Adult Hematology Saint\u2010Louis Hospital Institut de Recherche 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