{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:54:03Z","timestamp":1769925243394,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the efficacy and safety of pyrotinib in treating patients with human epidermal growth factor receptor type 2 (HER2)\u2010positive breast cancers with brain metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This is a multicenter retrospective study, and the HER2\u2010positive breast cancer patients with brain metastasis were studied. The enrolled patients were given pyrotinib 400\u00a0mg orally once per day for 21\u00a0days as one cycle, and evaluated every two cycles. All relevant data were detected for final assessments including medical history, clinical examination, histopathology, immunohistochemistry, radiographic imaging, treatment outcome, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two female patients in total were enrolled in this study. The objective response rate (ORR) and disease control rate (DCR) of central nervous system (CNS), were found in 20 of 42 (47.6%) and in 39 of 42 (92.8%), respectively, while for extra\u2010CNS, the respective ORR and DCR were in 9 of 38 (23.6%) and in 36 of 38 (94.7%), respectively. The compounded ORR and DCR were seen in 17 of 42 (40.4%) and in 39 of 42 (92.8%), respectively. The improvement rate of craniocerebral symptoms after treatment was (19\/19) 100% and the median duration was 15\u00a0months. The median effective time of brain metastases and other metastases was 43 and 50\u00a0days. The median follow\u2010up time was 22\u00a0months (interquartile range, 16.0\u201324.3\u00a0months). The median time for progression in brain metastasis was 16.6\u00a0months. The median time to progress for our group patients was 11.1\u00a0months. Sixteen patients (36%) with adverse reactions were recorded in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pyrotinib combined with chemotherapy\/radiotherapy or alone showed significantly greater local control rates and progression free survival (PFS), with manageable toxicity for patients with HER2\u2010positive breast cancer with brain metastases, and further follow\u2010up will provide an overall survival (OS) data.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4481","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T05:04:49Z","timestamp":1640667889000},"page":"735-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The efficacy and safety of pyrotinib in treating HER2\u2010positive breast cancer patients with brain metastasis: A multicenter study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1479-7914","authenticated-orcid":false,"given":"Min","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Radiation Therapy, Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Fu","sequence":"additional","affiliation":[{"name":"Chinese Medicine Hospital of Gaomi  Gaomi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"Zibo Municipal Hospital  Zibo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranran","family":"Zhang","sequence":"additional","affiliation":[{"name":"XueCheng Distict People Hospital  Zaozhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Qingdao Municipal Hospital Group  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbao","family":"Zong","sequence":"additional","affiliation":[{"name":"Qingdao Hospital of Traditional Chinese Medicine The affiliated Qingdao Hiser Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"liping","family":"Meng","sequence":"additional","affiliation":[{"name":"The third people's Hospital of Dezhou  Dezhou 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