{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:54:52Z","timestamp":1790060092571,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8162\/A16892"],"award-info":[{"award-number":["C8162\/A16892"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8162\/A25356"],"award-info":[{"award-number":["C8162\/A25356"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8640\/A23385"],"award-info":[{"award-number":["C8640\/A23385"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current guidelines recommend endoscopic surveillance for Barrett oesophagus (BE), but the value of surveillance is still debated. Using a combination of primary care, secondary care and cancer registry datasets, we examined the impact of a prior BE diagnosis, clinical and risk factors on survival from oesophageal cancer and adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of patients aged 50 and above diagnosed with malignant oesophageal cancer between 1993 and 2014 using Clinical Practice Research Datalink (CPRD). All prior BE diagnoses and endoscopies were identified from CPRD and Hospital Episode Statistics. Histology information was obtained from linked cancer registry data. We used flexible parametric models to estimate excess hazard ratios (EHRs) for relative survival. We simulated the potential impact of lead\u2010time by adding random lead\u2010times from a variety of distributions to all those with prior BE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among our oesophageal cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07503) and adenocarcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01476) cohorts only small percentages, 3.4% and 5.3%, respectively, had a prior BE diagnosis. Two\u2010year relative survival was better among patients with BE: 48.0% (95% CI 41.9\u201354.9) compared to 25.2% (24.3\u201326.2) without. Patients with BE had a better prognosis (EHR\u00a0=\u00a00.53, 0.41\u20130.68). Survival was higher even if patients with BE had fewer than two endoscopies (50.0%; 43.6\u201357.3). A survival benefit was still observed after lead\u2010time adjustment, with a 20% absolute difference in 2\u2010year survival using a 5\u00a0year mean sojourn time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with a prior BE diagnosis had a survival advantage. This was not fully explained by surveillance endoscopies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.4484","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T06:02:06Z","timestamp":1639634526000},"page":"1160-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Barrett oesophagus diagnoses and endoscopies on oesophageal cancer survival in the UK: A cohort study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5604-1635","authenticated-orcid":false,"given":"Judith","family":"Offman","sequence":"first","affiliation":[{"name":"Comprehensive Cancer Centre School of Cancer and Pharmaceutical Sciences Faculty of Life Sciences &amp; Medicine King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pesola","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Centre School of Cancer and Pharmaceutical Sciences Faculty of Life Sciences &amp; Medicine King\u2019s College London  London UK"},{"name":"Current affiliation: Health and Lifestyle Research Unit Wolfson Institute of Preventive Medicine Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"MRC Cancer Unit Hutchison\/MRC Research Centre University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willie","family":"Hamilton","sequence":"additional","affiliation":[{"name":"College of Medicine and Health University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sasieni","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Centre School of Cancer and Pharmaceutical Sciences Faculty of Life Sciences &amp; Medicine King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308124"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i34.5598"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305372"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02782.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0012"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0753"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103508"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.046"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i32.3672"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305997"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31388-6"},{"issue":"1720","key":"e_1_2_11_13_1","article-title":"Identification of prognostic phenotypes of esophageal adenocarcinoma in 2 independent cohorts","volume":"155","author":"Sawas T","year":"2018","journal-title":"Gastroenterology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv098"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2018.08.009"},{"key":"e_1_2_11_16_1","unstructured":"Cancer Research UK.Oesophageal cancer statistics.2018.https:\/\/www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/oesophageal\u2010cancer\/incidence#heading\u2010OneAccessed 15 October 2018"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/83.1.127"},{"key":"e_1_2_11_18_1","unstructured":"University of California Berkeley (USA) Max Planck Institute for Demographic Research (Germany).Human mortality database.2018.https:\/\/www.mortality.org\/Accessed 01 July 2018"},{"key":"e_1_2_11_19_1","unstructured":"SandersS Office for National Statistics.National Life Tables England & Wales 1980\u201082 to 2015\u201017.2018.https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/lifeexpectancies\/bulletins\/nationallifetablesunitedkingdom\/2015to2017Accessed 08 December 2021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0900900206"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3064"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1203"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-021495"},{"key":"e_1_2_11_24_1","unstructured":"LambertP.STPM2_STANDSURV: Stata module to obtain standardized survival curves after fitting an stpm2 survival model. 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