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These studies, combining oncological and neuroscientific approaches, created the basis for the emergence of a new field in oncology research, the so\u2010called \u201cneurobiology of cancer.\u201d The concept of the neurobiology of cancer is based on several facts: (a) psychosocial factors influence the incidence and progression of cancer diseases; (b) the nervous system affects DNA mutations and oncogene\u2010related signaling; (c) the nervous system modulates tumor\u2010related immune responses; (d) tumor tissues are innervated; (e) neurotransmitters released from nerves innervating tumor tissues affect tumor growth and metastasis; (f) alterations or modulation of nervous system activity affects the incidence and progression of cancers; (g) tumor tissue affects the nervous system. 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