{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:40:08Z","timestamp":1765888808808,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the clinical characteristics of metachronous second primary malignancies (Met\u2010SPMs) and its impact on prognosis in hypopharyngeal carcinoma (HPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 593 newly diagnosed HPC patients without invasive synchronous SPMs (Syn\u2010SPMs) who were treated in our cancer center between 2009 and 2019. According to the status during follow\u2010up, patients were classified into three groups: (a) without SPMs (No\u2010SPMs, <jats:italic>n<\/jats:italic>\u00a0=\u00a0440), (b) with tumors in situ in the esophagus or stomach (Tis, <jats:italic>n<\/jats:italic>\u00a0=\u00a080), or (c) with Met\u2010SPMs (<jats:italic>n<\/jats:italic>\u00a0=\u00a073).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time for entire cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0593) was 66.7\u00a0months. Met\u2010SPMs were present in 12.3% of the cohort (73\/593). The predominant site of SPMs was esophagus, followed by lung, oral cavity, thyroid, stomach, and oropharynx. In Met\u2010SPMs group, both index tumor and SPMs were the main causes of death. Tis group exhibited comparable 5\u2010year overall survival (OS) and disease\u2010specific survival (DSS) with that of No\u2010SPMs group. The Met\u2010SPMs group had similar 5\u2010year OS rate and better 5\u2010year DSS rate of 47.3% versus 43.6% (odds ratio [OR], 0.931; 95% confidence interval [CI], 0.681\u20131.274, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.657) and 66.3% vs. 46.2% (OR, 0.600; 95% CI, 0.402\u20130.896, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012), respectively, compared with the No\u2010SPMs group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall incidence of Met\u2010SPMs in HPC was 12.3%. The occurrence of Met\u2010SPMs does not jeopardize the survival outcome of HPC. Routine surveillance of Met\u2010SPMs was requisite for patients with HPC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4501","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T09:40:27Z","timestamp":1643190027000},"page":"1059-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the prevalence of metachronous second primary malignancies in hypopharyngeal carcinoma and their effect on outcomes"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-9644","authenticated-orcid":false,"given":"Xi","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, 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