{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:01:46Z","timestamp":1783425706109,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502230"],"award-info":[{"award-number":["81502230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971340"],"award-info":[{"award-number":["81971340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (HPV) infection is the main cause of female precancerous lesions and cervical cancer. The development and application of HPV prophylactic vaccines have been recognized as a major effective intervention for the control of cervical lesions. However, the infection rate and clinical characters of non\u20109\u2010valent vaccine covered HPV subtypes are still worth studying. In this retrospective study, we included patients diagnosed and treated in the Department of Gynecology of Shanghai General Hospital between January 2017 and February 2021. The clinical features of non\u20109\u2010valent vaccine covered HPV subtypes were explored in 2179 patients who have normal results, 338 patients with cervical intraepithelial neoplasia 1 (CIN1), and 153 patients with \u2265CIN2. Univariate analysis showed that compared to the normal cervix group, age \u226550, pregnancy \u22655, delivery \u22653, menopause, no condom use, and cervical transformation zone type III were risk factors for CIN1 or \u2265CIN2 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Thirty\u2010one percent of CIN1 and 26% of \u2265CIN2 were attributed to HPV51, HPV53, HPV56, and HPV68. Multivariate analysis revealed that HPV53, HPV81, age, menopause, cervical transformation area and involved glands were independent risk factors for \u2265CIN2\u00a0group compared to the CIN1\u00a0group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Additionally, among the 14 non\u20109\u2010valent vaccine covered HPV subtypes, the infection rates of HPV53, 56, 51, and 68 were higher in this study. In conclusion, our study demonstrated the distribution and pathogenic risk of non\u20109\u2010valent vaccine covered HPV subtypes in cervical lesions. These findings might supply a foundation for optimizing cervical cancer prevention in the post\u2010vaccine era.<\/jats:p>","DOI":"10.1002\/cam4.4532","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T05:03:13Z","timestamp":1641272593000},"page":"1542-1552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The distribution and pathogenic risk of non\u20109\u2010valent vaccine covered HPV subtypes in cervical lesions"],"prefix":"10.1002","volume":"11","author":[{"given":"Mingjun","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfen","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai General Hospital School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-776X","authenticated-orcid":false,"given":"Jiawen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"},{"name":"Reproductive Medicine Center Department of Obstetrics and Gynecology Shanghai General Hospital School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shanghai General Hospital School of Medicine Shanghai Jiao Tong University  Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.12.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-5-19"},{"issue":"15","key":"e_1_2_10_5_1","first-page":"118","article-title":"Human papillomavirus vaccines. WHO position paper","volume":"84","year":"2009","journal-title":"Releve Epidemiologique Hebdomadaire"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30120-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.08.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.185"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.78"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70158-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1999.99020.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-2945-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30298-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01512-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26404"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12184"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30068-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30099-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1779"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(65)90022-3"},{"issue":"1","key":"e_1_2_10_21_1","first-page":"117","article-title":"Site and origin of squamous cervical cancer: a histomorphologic study","volume":"62","author":"Burghardt E","year":"1983","journal-title":"Obstet Gynecol"},{"issue":"05","key":"e_1_2_10_22_1","first-page":"371","article-title":"Relationship between different types of cervical transformation zone and cervical intraepithelial neoplasia","volume":"25","author":"Huang J","year":"2009","journal-title":"Chinese J Pract Gynecol Obstet"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4330-9"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01157.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600688"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.11.005"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4313-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405044"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3066"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24731"},{"issue":"11","key":"e_1_2_10_31_1","first-page":"1261","article-title":"Study on the distribution and risk of human papillomavirus subtypes in cervical diseases","volume":"35","author":"Zhu H","year":"2019","journal-title":"Chinese J Pract Gynecol Obstet"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22751"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-171050"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.14971"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24528"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4532","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T11:47:44Z","timestamp":1693136864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,3]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/cam4.4532"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4532","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,3]]},"assertion":[{"value":"2021-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}