{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:05:00Z","timestamp":1790532300391,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is sparse clinical information on the racial and ethnic distribution of results of multigene panel testing among individuals at high risk for hereditary cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the results of multigene panel testing across eight clinical sites across the state of Michigan for individuals seen for genetic counseling from May 13, 2013 to October 31, 2019 at the Karmanos Cancer Institute's cancer genetics clinic. We estimated the prevalence of pathogenic variants and variants of uncertain significance (VUS) from genes other than <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> among individuals of non\u2010Hispanic White (NHW), Black or African American (AA), Ashkenazi Jewish (AJ), Arab, Hispanic, and other ancestry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The racial and ethnic distribution of 2419 individuals who had panel testing included 68.8% NHW, 22.1% AA, 2.3% Arab, 2.2% AJ, 1.0% Hispanic, and 3.6% other. Of these, 11.2% had pathogenic variants and 17.5% had VUS. After multivariable analyses, compared to NHW, AA were less likely to have pathogenic variants (OR 95% CI, 0.38, 0.24\u20130.59, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Both AA and Arabs were more likely to have VUS (OR 95% CI, 1.53, 1.18\u20131.98, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.001 and OR 95% CI, 2.28, 1.17\u20134.43, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.015, respectively). There were no significant differences for other groups. The most common pathogenic variants were <jats:italic>CHEK2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a065), <jats:italic>MUTYH<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a045), <jats:italic>ATM<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a028), and <jats:italic>MSH2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a022); the most common pathogenic variants by race and ethnicity were <jats:italic>CHEK2<\/jats:italic> (NHW), <jats:italic>MSH2<\/jats:italic> and <jats:italic>MUTYH<\/jats:italic> (AA), <jats:italic>MSH2<\/jats:italic> (Arab), <jats:italic>MSH6<\/jats:italic> and <jats:italic>CHEK2<\/jats:italic> (AJ), and <jats:italic>MLH1<\/jats:italic> (Hispanic); the most common pathogenic variants by primary cancer site were <jats:italic>CHEK2<\/jats:italic> (breast), <jats:italic>MSH2<\/jats:italic> (colon), <jats:italic>BRIP1<\/jats:italic> and <jats:italic>MUTYH<\/jats:italic> (ovarian), and <jats:italic>MSH2<\/jats:italic> and <jats:italic>MSH6<\/jats:italic> (endometrial).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Understanding the racial and ethnic distribution of pathogenic variants in multi\u2010gene panels has the potential to lead to better identification of individuals at risk for hereditary cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4541","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T03:59:37Z","timestamp":1642478377000},"page":"1465-1473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Racial and ethnic variation in multigene panel testing in a cohort of <i>BRCA1\/2<\/i>\u2010negative individuals who had genetic testing in a large urban comprehensive cancer center"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-1649","authenticated-orcid":false,"given":"Sushma","family":"Tatineni","sequence":"first","affiliation":[{"name":"Minnesota Oncology  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meri","family":"Tarockoff","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Memorial Healthcare System  Pembroke Pines Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-1589","authenticated-orcid":false,"given":"Nadine","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-1692","authenticated-orcid":false,"given":"Kristen\u00a0S.","family":"Purrington","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Population Studies and Disparities Research Program Barbara Ann Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-0199","authenticated-orcid":false,"given":"Hadeel","family":"Assad","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Population Studies and Disparities Research Program Barbara Ann Karmanos Cancer Institute  Detroit Michigan 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