{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:39:03Z","timestamp":1747147143423,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82070913"],"award-info":[{"award-number":["NSFC 82070913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study examined and compared the attitudes and willingness of guardians of children with cancer and adult cancer patients toward donating biospecimens and clinical data for cancer research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study among guardians of children with cancer (Guardian group) from Shanghai Children's Medical Center and adult cancer patients (Adult group) from Shanghai Ninth People's Hospital between February 1, 2019, and January 31, 2020. Participants\u2019 demographic data, willingness, and motivations for biospecimen donation were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 670 participants, 90.8% (318\/350) in the Guardian group and 88.1% (282\/320) in the Adult group completed the questionnaire. Most participants were willing to donate residual tissue samples (92.8% in the Guardian group vs. 79.4% in the Adult group, <jats:italic>p<\/jats:italic><jats:sup>\u03c8<\/jats:sup>\u00a0=\u00a00.032) and clinical data (94.0% vs. 72.3%, <jats:italic>p<\/jats:italic><jats:sup>\u03c8<\/jats:sup>\u00a0&lt;\u00a00.001) for medical research. Logistic regression analysis indicated that only child status (odds ratio [OR]\u00a0=\u00a00.140, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), history of blood donation (OR\u00a0=\u00a04.467, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019) in the Guardian group, education (OR\u00a0=\u00a00.387, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037), and history of blood donation (OR\u00a0=\u00a02.556, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016) in the Adult group were significantly associated with participants\u2019 willingness to donate biospecimens. The primary motivation for donation was helping other patients with cancer (65.4% vs. 24.5%, <jats:italic>p<\/jats:italic><jats:sup>\u03c8<\/jats:sup>\u00a0&lt;\u00a00.001). The major barriers to donation were the potential to cause physical discomfort (61.0% vs. 64.9%, <jats:italic>p<\/jats:italic><jats:sup>\u03c8<\/jats:sup>\u00a0=\u00a00.032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Guardians of children with cancer were more willing to donate biospecimens than adult cancer patients in China. It is essential to promote awareness of biospecimens donation, especially in adult cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4544","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T08:38:39Z","timestamp":1643877519000},"page":"1524-1534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of factors influencing the willingness to donate biospecimens among guardians of children with cancer and adult cancer patients"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4566-2214","authenticated-orcid":false,"given":"Hongxiang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pediatric General Surgery Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baige","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology &amp; Metabolism Shanghai Fourth People's Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Operating Room Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqi","family":"Shi","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Cell Therapy Shanghai East Hospital Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-463X","authenticated-orcid":false,"given":"Shijian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Pediatric Health Advocacy Institute Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"School of Public Health Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8645-1114","authenticated-orcid":false,"given":"Congrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology &amp; 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