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Then, we screened out 8, 16, and 29 module genes from these DEGs, respectively. Next, 10 candidate genes were determined through expression and survival analyses. We noted that seven candidate genes JUN<\/jats:italic>, FOS<\/jats:italic>, FOSB<\/jats:italic>, EGR1<\/jats:italic>, ZFP36<\/jats:italic>, CFD<\/jats:italic>, and PPARG<\/jats:italic> were downregulated in BC compared to normal tissues and lower expressed in aggressive types of BC (basal, HER2+<\/jats:sup>, and luminal B), TP53<\/jats:italic> mutation group, younger patients, higher stage BC, and lymph node metastasis BC, while CD27<\/jats:italic>, PSMB9<\/jats:italic>, and SELL<\/jats:italic> were upregulated. The present study discovered that the expression levels of these candidate genes were correlated with the infiltration of immune cells (CD8+<\/jats:sup> T cell, macrophage, natural killer [NK] cell, and cancer\u2010associated fibroblast) in BC, as well as biomarkers of immune cells and immune checkpoints. We also revealed that promoter methylation, amplification, and deep deletion might contribute to the abnormal expressions of candidate genes. Moreover, we illustrated downstream\u2010targeted genes of JUN<\/jats:italic>, FOS<\/jats:italic>, FOSB<\/jats:italic>, EGR1<\/jats:italic>, and ZFP36<\/jats:italic> and demonstrated that these targeted genes were involved in \u201cpositive regulation of cell death\u201d, \u201cpathways in cancer\u201d, \u201cPI3K\u2010Akt signaling pathway\u201d, and so on.<\/jats:p><\/jats:sec>Discussion & Conclusion<\/jats:title>We presented differential gene expression profiles among normal, para\u2010cancerous, and BC tissues and further identified candidate genes that might contribute to tumorigenesis and progression of BC, as potential diagnostic and prognostic targets for BC 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