{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:21:36Z","timestamp":1785878496112,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008271","name":"LEO Pharma Research Foundation","doi-asserted-by":"publisher","award":["Thrombosis and Cancer"],"award-info":[{"award-number":["Thrombosis and Cancer"]}],"id":[{"id":"10.13039\/501100008271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thromboembolic events frequently complicate the course of malignancy and represent a major cause of morbidity and mortality in cancer patients. In contrast to chemotherapy and other systemic therapies, little is known about the impact of ionizing radiations on the incidence of venous thromboembolism (VTE) in cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present prospective study, we aimed to investigate the incidence, management, and outcome of VTE in newly diagnosed cancer patients who received curative radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VTE was found in 8 patients, out of 401 patients at a median time of 80\u00a0days after radiotherapy initiation. The incidence rate of VTE at 6\u00a0months post\u2010treatment was 2% (95% CI, 0.9\u20133.7), with 50% of cases occurring during the radiotherapy course and 50% of cases in patients who received or were receiving chemotherapy. As none of the patients harbored a personal history of VTE, no prophylactic measure was initiated during cancer therapy. Most patients received monotherapy with low\u2010molecular\u2010weight heparin and were still on surveillance at the end of the study. No specific clinical risk factor was identified that might systematically indicate the need of thromboprophylaxis in the context of curative radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although this <jats:italic>pan<\/jats:italic>\u2010cancer descriptive study did not relate an increased risk of short\u2010term thrombosis following ionizing radiation, it provides important insight as a basis for future studies with subcategories of cancer, in order to <jats:italic>in fine<\/jats:italic> guide further recommendations in frail patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration number<\/jats:title><jats:p>NCT02696447.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4559","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T08:47:35Z","timestamp":1645692455000},"page":"1753-1762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Venous thromboembolism and radiation therapy: The final <scp>radiation\u2010induced<\/scp> thrombosis study analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-1016","authenticated-orcid":false,"given":"Elisabeth","family":"Daguenet","sequence":"first","affiliation":[{"name":"D\u00e9partement Universitaire de la Recherche et de l'Enseignement Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"},{"name":"D\u00e9partement de Radioth\u00e9rapie Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Maison","sequence":"additional","affiliation":[{"name":"D\u00e9partement Universitaire de la Recherche et de l'Enseignement Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"},{"name":"D\u00e9partement de Radioth\u00e9rapie Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Tinquaut","sequence":"additional","affiliation":[{"name":"D\u00e9partement Universitaire de la Recherche et de l'Enseignement Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric\u2010Alban","family":"Giroux","sequence":"additional","affiliation":[{"name":"D\u00e9partement Universitaire de la Recherche et de l'Enseignement Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bertoletti","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Vasculaire et Th\u00e9rapeutique CHU de St\u2010Etienne  Saint\u2010Etienne France"},{"name":"INSERM, UMR1059, Equipe Dysfonction Vasculaire et H\u00e9mostase Universit\u00e9 Jean\u2010Monnet  Saint\u2010Etienne France"},{"name":"INSERM  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Suchaud","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Radioth\u00e9rapie Centre Hospitalier de Roanne  Roanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Rancoule","sequence":"additional","affiliation":[{"name":"D\u00e9partement Universitaire de la Recherche et de l'Enseignement Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"},{"name":"D\u00e9partement de Radioth\u00e9rapie Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Baptiste","family":"Guy","sequence":"additional","affiliation":[{"name":"D\u00e9partement Universitaire de la Recherche et de l'Enseignement Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Magn\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement Universitaire de la Recherche et de l'Enseignement Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"},{"name":"D\u00e9partement de Radioth\u00e9rapie Institut de Canc\u00e9rologie Lucien Neuwirth  St\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0214"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-460121"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1311-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-08-0615"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.6.715"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-07-0603"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2018.02.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.3271"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00222-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2956-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209825"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.01.421"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1572"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2013.10.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26102"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.03.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2015.48580"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605883"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.12.008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108898"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.83"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-016-0078-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(09)70137-9"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00928.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.e18289"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13051033"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.01.218"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116327"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0414"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.073338"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1313-4"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30336-5"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr392"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01461"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.209114"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:49:36Z","timestamp":1692294576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,24]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/cam4.4559"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4559","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,24]]},"assertion":[{"value":"2021-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}